Volume 12, Issue 3 (Scientific Journal of Hamadan University of Medical Sciences-Autumn 2005)                   Avicenna J Clin Med 2005, 12(3): 36-41 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nasiri E, Dehpour A R, Zamani A R, Amiri I. Effect of Obstructive Cholestasis on Sperm Parameters in the Adult Male Rats. Avicenna J Clin Med 2005; 12 (3) :36-41
URL: http://sjh.umsha.ac.ir/article-1-534-en.html
1- , ebrahimnasiri@yahoo.com
Abstract:   (4321 Views)

Introduction & Objective: Obstructive cholestasis is associated with overproduction of endogenous opioids , nitric oxide and cytokins in the blood streams. These consequences may affect sex hormones since proper fertility will be resulted from physiological balance of sex hormones, we investigated the relationship between obstructive cholestasis and gonadotropins and sperm parameters in adult male rats.

Materials & Methods: To study this, we used three groups of animals: control (No-surgery), Sham (surgical control), and cholestatic (surgical ligation of the bile duct). After 3 weeks all animals were killed by ether, and serum concentrations of FSH and LH were determined by radioimmunoassay, sperm parameters were evaluated by light microscop.

Results: The findings of this study showed that LH and FSH levels decreased significantly in cholestatic compared to control and sham groups (p<0.05). On the other hand, we did not find any significant difference in sperm parameters between cholestatic and other groups (P>0.05).

Conclusion: These findings indicated that obstructive cholestasis lead to decrease in the levels of serum gonadotropins, but it has no significant effect on sperm parameters. We speculated that spermatogenesis, and sperm parameters were not dependent on gonadotropin hormones but other factors may involved.

Full-Text [PDF 243 kb]   (2502 Downloads)    
Type of Study: Original | Subject: Other Clinical Specialties

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Avicenna Journal of Clinical Medicine

Designed & Developed by : Yektaweb