Volume 8, Issue 3 (Scientific Journal of Hamadan University of Medical Sciences-Autumn 2001)                   Avicenna J Clin Med 2001, 8(3): 0-0 | Back to browse issues page

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Ghaforian Borojerdnia M. A Histopathological Study of Effects of Intraperitoneal Garlic Extract on Liver in Rats. Avicenna J Clin Med 2001; 8 (3)
URL: http://sjh.umsha.ac.ir/article-1-845-en.html
Abstract:   (4364 Views)

In recent years, many investigations have reported the  pharmaceutical
   effects of garlic such as antibacterial, antihypertension, antithrombotic,
   anticarcinogenic and many others. Studies suggest that garlic may has
   toxic effects on body tissues. In this study,  histopathological effects of garlic
   extract on liver tissue in rats were investigated.

          The animals were divided into five groups including control group 
   (received saline) and four experimental groups (received garlic extract, 50,
   100, 200 and 400mg/kg intraperitonally for a month). The sections of liver
   tissue were stained by H&E method for histopathological examination.

          The histopathological examination indicated that administration of low
   dose of garlic (50mg/Kg) has little effects on liver tissue in comparison with
   the control animals. However, administration of high dose of garlic
   (400mg/kg) induce considerable damage on this tissue in comparison to
   other groups.

          Although the use of garlic is useful for body, the consumption of high
   levels of garlic may induce toxic effects on body tissues. Therefore, further
   studies are needed before garlic preparations can be used as medicine.


Type of Study: Original | Subject: Other Clinical Specialties

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