Volume 32, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2025)
Avicenna J Clin Med 2025, 32(1): 13-20 |
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Hadei S K, Azhand M, Fariba F. Investigating the Relationship between Calcium Score in Coronary Arteries and Aortic Valve in Predicting the Risk of Cardiovascular Events on Cardiac Computed Tomography Angiography. Avicenna J Clin Med 2025; 32 (1) :13-20
URL: http://sjh.umsha.ac.ir/article-1-3197-en.html
URL: http://sjh.umsha.ac.ir/article-1-3197-en.html
1- Department of Radiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Radiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran ,ajandmina1@gmail.com
3- Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Radiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran ,
3- Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract: (84 Views)
Background and Objective: Coronary artery and aortic valve calcium measurement is a low-cost, fast, and without the need for injection of contrast media, which is important in determining the severity of atherosclerosis and the prognosis of heart disease. In this regard, this study aimed to assess the relationship between coronary artery calcium score and aortic valve calcification in order to predict the risk of cardiovascular diseases.
Materials and Methods: This descriptive/cross-sectional study was conducted on 300 patients suspected of having coronary artery stenosis, candidates for coronary computed tomography (CT) angiography, who were selected via convenience and consecutive sampling methods. In CT angiography before the injection of contrast material, the calcium score in the coronary vessels and aortic valve were measured and graded according to Agatston criteria. Moreover, 3-mm chest sections were used to calculate the calcium score using the Siemens 128 CT scanner software. Data analysis was performed using SPSS software (version 26), and Spearman's correlation coefficient was employed to determine the correlation between coronary artery calcium score and aorta.
Results: A positive and significant correlation was found between aortic and coronary artery calcium scores (r=0.383, P<0.001). Moreover, body mass index, hypertension, and dyslipidemia were correlated with aortic and coronary artery calcium scores. In addition, a significant relationship was detected between diabetes and aortic calcium score. However, aortic and coronary calcium scores demonstrated no association with gender, age, and smoking.
Conclusion: The degree of aortic valve calcification is correlated with coronary artery calcification. Therefore, the aortic valve calcium score can also be used to predict the risk of atherosclerosis in the coronary arteries and cardiovascular events
Materials and Methods: This descriptive/cross-sectional study was conducted on 300 patients suspected of having coronary artery stenosis, candidates for coronary computed tomography (CT) angiography, who were selected via convenience and consecutive sampling methods. In CT angiography before the injection of contrast material, the calcium score in the coronary vessels and aortic valve were measured and graded according to Agatston criteria. Moreover, 3-mm chest sections were used to calculate the calcium score using the Siemens 128 CT scanner software. Data analysis was performed using SPSS software (version 26), and Spearman's correlation coefficient was employed to determine the correlation between coronary artery calcium score and aorta.
Results: A positive and significant correlation was found between aortic and coronary artery calcium scores (r=0.383, P<0.001). Moreover, body mass index, hypertension, and dyslipidemia were correlated with aortic and coronary artery calcium scores. In addition, a significant relationship was detected between diabetes and aortic calcium score. However, aortic and coronary calcium scores demonstrated no association with gender, age, and smoking.
Conclusion: The degree of aortic valve calcification is correlated with coronary artery calcification. Therefore, the aortic valve calcium score can also be used to predict the risk of atherosclerosis in the coronary arteries and cardiovascular events
References
1. Yekke Fallah L, Pournorouz Ghad M, Nouri Sari H, Alipour M. Evaluating the time interval between calling emergency medical services and undergoing primary percutaneous coronary intervention in patients with acute myocardial infarction. Iran Jour Emerg Med. 2017;4(3):118-124. DOI:10.22037/ijem.v2i1.16581
2. Zamani B, Azari M, Hosseinian A, ShokrDargahy A, Mardi A, Azari S. Effect of the injection speed of streptokinase in patients with acute MI admitted to the cardiac intensive care section of Imam Khomeiny hospital in Ardabil 2011-2012. J Ardabil Univ Med Sci. 2015; 15 (2) :128-136. Link
3. Abdi H, Azamian Jazi A, Hafezi MR, Khaksari M, Shamsaei N. The combined effect of endurance training and various doses of atorvastatin on cardiac remodeling after myocardial infarction in male rats. J Knowledge Health. 2016;11(1):32-40 . Link
4. Oliveira GB, Avezum A, Roever L. Cardiovascular disease burden: Evolving knowledge of risk factors in myocardial infarction and stroke through population-based research and perspectives in global prevention. Front Cardiovasc Med. 2015;2:32. PMID: 26664903 DOI: 10.3389/fcvm.2015.00032
5. Brown JC, Gerhardt TE, Kwon E. Risk factors for coronary artery disease. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2024. PMID: 32119297
6. Ralapanawa U, Sivakanesan R. Epidemiology and the magnitude of coronary artery disease and acute coronary syndrome: A narrative review. J Epidemiol Glob Health. 2021;11(2):169-177. PMID: 33605111 DOI: 10.2991/jegh.k.201217.00
7. Hollenberg EJ, Lin F, Blaha MJ, Budoff MJ, van den Hoogen IJ, Gianni U, et al. Relationship between coronary artery calcium and atherosclerosis progression among patients with suspected coronary artery disease. JACC Cardiovasc Imaging. 2022;15(6):1063-1074. PMID: 35680215 DOI: 10.1016/j.jcmg.2021.12.015
8. Al Rifai M, Kanaya AM, Kandula NR, Patel J, Al-Mallah MH, Budoff M, et al. Association of coronary artery calcium density and volume with predicted atherosclerotic cardiovascular disease risk and cardiometabolic risk factors in south Asians: The mediators of atherosclerosis in south Asians living in America (MASALA) study. Curr Probl Cardiol. 2023;48(4):101105. PMID: 34999157 DOI: 10.1016/j.cpcardiol.2022.101105
9. Suwita, BM, Suroyo, I, Rusdi, L, Prihartono J. The correlation between coronary artery, aortic, and mitral valve calcification in patients with coronary atherosclerosis. Egypt J Radiol Nucl Med. 2023;54:108. DOI:10.1186/s43055-023-01053-6
10. Hou ZH, Lu B, Gao Y, Jiang SL, Wang Y, Li W, et al. Prognostic value of coronary CT angiography and calcium score for major adverse cardiac events in outpatients. JACC Cardiovasc Imaging. 2012;5(10):990-999. PMID: 23058065 DOI: 10.1016/j.jcmg.2012.06.006
11. Koulaouzidis G, Nicoll R, MacArthur T, Jenkins PJ, Henein MY. Coronary artery calcification correlates with the presence and severity of valve calcification. Int J Cardiol. 2013;168(6):5263-5266. PMID: 23993324DOI: 10.1016/j.ijcard.2013.08.019
12. Nasir K, Katz R, Al-Mallah M, Takasu J, Shavelle DM, Carr JJ, et al. Relationship of aortic valve calcification with coronary artery calcium severity: the Multi-Ethnic Study of Atherosclerosis (MESA). J Cardiovasc Comput Tomogr. 2010;4(1):41-6. PMID: 20159627 DOI: 10.1016/j.jcct.2009.12.002
13. Senoner T, Plank F, Beyer C, Langer C, Birkl K, Steinkohl F, et al. Gender differences in the atherosclerosis profile by coronary CTA in coronary artery calcium score zero patients. J Clin Med. 2021;10(6):1220. PMID: 33804095 DOI: 10.3390/jcm10061220
14. Jensen JC, Dardari ZA, Blaha MJ, White S, Shaw LJ, Rumberger J, et al. Association of body mass index with coronary artery calcium and subsequent cardiovascular mortality: The coronary artery calcium consortium. Circ Cardiovasc Imaging. 2020;13(7): e009495. PMID: 32660258 DOI: 10.1161/CIRCIMAGING.119.009495
15. Wong ND, Sciammarella MG, Polk D, Gallagher A, Miranda-Peats L, Whitcomb B, et al. The metabolic syndrome, diabetes, and subclinical atherosclerosis assessed by coronary calcium. J Am Coll Cardiol. 2003;41(9):1547-1553. PMID: 12742296 DOI: 10.1016/s0735-1097(03)00193-1
16. Sung J, Lim SJ, Choe Y, Choi YH, Lee MK, Lee SH, et al. Comparison of the coronary calcium score with the estimated coronary risk. Coron Artery Dis. 2008; 19(7):475-479. PMID: 18923243 DOI: 10.1097/MCA.0b013e3283078f9f
17. Gupta A, Bera K, Kikano E, Pierce JD, Gan J, Rajdev M, et al. Coronary artery calcium scoring: current status and future directions. Radiographics. 2022;42(4):947-967. PMID: 35657766 DOI: 10.1148/rg.210122
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