Volume 32, Issue 4 (Avicenna Journal of Clinical Medicine-Winter 2026)
Avicenna J Clin Med 2026, 32(4): 202-208 |
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Monajjem M M, Rasuli Nia A A, Jiryaee N. Association of Complete Blood Cell Count-Derived Inflammatory Indices with the Severity of Coronary Artery Disease in a Young and Middle-Aged Iranian Population. Avicenna J Clin Med 2026; 32 (4) :202-208
URL: http://sjh.umsha.ac.ir/article-1-3271-en.html
URL: http://sjh.umsha.ac.ir/article-1-3271-en.html
1- Clinical Research Development Unit of Farshchian Heart Center, Hamadan University of Medical Sciences, Hamadan, Iran & Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , m.monajjem97@gmail.com
2- Clinical Research Development Unit of Farshchian Heart Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Social Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Clinical Research Development Unit of Farshchian Heart Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Social Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract: (87 Views)
Background and Objective: Coronary artery disease (CAD) is a leading cause of death worldwide, and inflammation plays a key role in its pathogenesis. This study aimed to investigate the association of complete blood cell count (CBC)-derived inflammatory indices with the angiographic severity of CAD.
Materials and Methods: In this retrospective cross-sectional study, the records of 236 patients (189 men, 47 women) with a mean age of 47.9 ± 5.4 years who underwent elective coronary angiography were reviewed. The severity of CAD was determined using the SYNTAX score. Demographic data, CBC.diff parameters (including neutrophil to lymphocyte ratio [NLR] and platelet-to-lymphocyte ratio [PLR]), and levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were collected and analyzed using SPSS (version 16) and appropriate statistical tests.
Results: In the overall analysis, levels of white blood cell (P = 0.046), neutrophil (P = 0.002), NLR (P = 0.012), PLR (P = 0.032), hematocrit (P = 0.020), ESR (P < 0.001), and CRP (P = 0.004) all showed a statistically significant association with the severity of CAD. These associations were particularly stronger in men and individuals over 45 years of age. In contrast, none of the parameters showed a significant association in the female population, and lymphocyte count, platelet count, and hemoglobin also showed no significant association in the total sample.
Conclusion: Simple and cost-effective CBC-derived inflammatory indices, especially ESR, neutrophil count, NLR, and CRP, have a significant correlation with the severity of CAD. They can be used as useful preliminary screening tools to identify high-risk patients and assist in prioritizing them for coronary angiography.
Materials and Methods: In this retrospective cross-sectional study, the records of 236 patients (189 men, 47 women) with a mean age of 47.9 ± 5.4 years who underwent elective coronary angiography were reviewed. The severity of CAD was determined using the SYNTAX score. Demographic data, CBC.diff parameters (including neutrophil to lymphocyte ratio [NLR] and platelet-to-lymphocyte ratio [PLR]), and levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were collected and analyzed using SPSS (version 16) and appropriate statistical tests.
Results: In the overall analysis, levels of white blood cell (P = 0.046), neutrophil (P = 0.002), NLR (P = 0.012), PLR (P = 0.032), hematocrit (P = 0.020), ESR (P < 0.001), and CRP (P = 0.004) all showed a statistically significant association with the severity of CAD. These associations were particularly stronger in men and individuals over 45 years of age. In contrast, none of the parameters showed a significant association in the female population, and lymphocyte count, platelet count, and hemoglobin also showed no significant association in the total sample.
Conclusion: Simple and cost-effective CBC-derived inflammatory indices, especially ESR, neutrophil count, NLR, and CRP, have a significant correlation with the severity of CAD. They can be used as useful preliminary screening tools to identify high-risk patients and assist in prioritizing them for coronary angiography.
Keywords: Angiography, Complete blood count, Coronary artery disease, Neutrophil-to-lymphocyte ratio
Type of Study: Original |
Subject:
Cardiovascular Diseases
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