Volume 32, Issue 4 (Avicenna Journal of Clinical Medicine-Winter 2026)
Avicenna J Clin Med 2026, 32(4): 195-201 |
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Ghasemibasir H, khanlarzade E, Bakhtiari R, Jamshidi M. Evaluation of Serum Level of Adenosine Deaminase in Patients with Plaque Psoriasis before and after Topical Treatment. Avicenna J Clin Med 2026; 32 (4) :195-201
URL: http://sjh.umsha.ac.ir/article-1-3292-en.html
URL: http://sjh.umsha.ac.ir/article-1-3292-en.html
1- Department of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Social Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Dermatology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran ,jamshidim84@yahoo.com
2- Department of Social Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Dermatology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract: (108 Views)
Background and Objective: Adenosine deaminase is an enzyme that plays a role in the catabolism of purine bases, and uric acid is the final product of purine base metabolism. This study aimed to determine the serum level of adenosine deaminase in patients with plaque psoriasis before and after topical treatments and compare it with the control group.
Materials and Methods: In this case-control study conducted at the dermatology clinic of Sina Farshchian Hospital in Hamadan (2022), serum levels of adenosine deaminase and uric acid were measured in 30 patients with psoriasis and 30 age- and sex-matched healthy controls using the ELISA method. Disease severity was evaluated using the Psoriasis Area and Severity Index (PASI). Statistical analyses were performed using SPSS version 20, and Kolmogorov-Smirnov test, Mann-Whitney U test, Wilcoxon, Pearson’s correlation, t-test and categorical variables were compared using the Chi-square test. A p-value of < 0.05 was considered statistically significant.
Results: Both groups had no statistically significant difference in terms of age and sex. The average BMI in the patient group was 28.38 and in the control group was 25.50. The level of adenosine deaminase in the patient group (before treatment) was significantly higher than the control group (P=0.002). The level of uric acid in the patient group (before treatment) was significantly higher than the control group (P=0.001). Adenosine deaminase level decreased significantly after treatment (P=0.01). Uric acid level decreased significantly after treatment (P=0.03). The severity of the disease (PASI score) decreased significantly after the treatment (P=0.03). There is a positive, direct and significant relationship between the level of uric acid and the severity of the disease, that is, with higher uric acid, the severity of the disease increases (P =0.039). There is no significant relationship between the variables of age, BMI and disease severity (PASI score) and adenosine deaminase.
Conclusion: The level of adenosine deaminase and uric acid in patients with plaque psoriasis is higher than that of healthy people, and their levels decrease after treatment. There is a direct relationship between the level of uric acid and the severity of the disease.
Materials and Methods: In this case-control study conducted at the dermatology clinic of Sina Farshchian Hospital in Hamadan (2022), serum levels of adenosine deaminase and uric acid were measured in 30 patients with psoriasis and 30 age- and sex-matched healthy controls using the ELISA method. Disease severity was evaluated using the Psoriasis Area and Severity Index (PASI). Statistical analyses were performed using SPSS version 20, and Kolmogorov-Smirnov test, Mann-Whitney U test, Wilcoxon, Pearson’s correlation, t-test and categorical variables were compared using the Chi-square test. A p-value of < 0.05 was considered statistically significant.
Results: Both groups had no statistically significant difference in terms of age and sex. The average BMI in the patient group was 28.38 and in the control group was 25.50. The level of adenosine deaminase in the patient group (before treatment) was significantly higher than the control group (P=0.002). The level of uric acid in the patient group (before treatment) was significantly higher than the control group (P=0.001). Adenosine deaminase level decreased significantly after treatment (P=0.01). Uric acid level decreased significantly after treatment (P=0.03). The severity of the disease (PASI score) decreased significantly after the treatment (P=0.03). There is a positive, direct and significant relationship between the level of uric acid and the severity of the disease, that is, with higher uric acid, the severity of the disease increases (P =0.039). There is no significant relationship between the variables of age, BMI and disease severity (PASI score) and adenosine deaminase.
Conclusion: The level of adenosine deaminase and uric acid in patients with plaque psoriasis is higher than that of healthy people, and their levels decrease after treatment. There is a direct relationship between the level of uric acid and the severity of the disease.
Type of Study: Original |
Subject:
Dermatology
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