Volume 23, Issue 2 (Scientific Journal of Hamadan University of Medical Sciences-Summer 2016)                   Avicenna J Clin Med 2016, 23(2): 126-133 | Back to browse issues page

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Khajeh Jahromi S, Mohammadghasemi F. Effect of Various Doses of Nicotine on Mitotic Index in Esophageal Mucosa. Avicenna J Clin Med. 2016; 23 (2) :126-133
URL: http://sjh.umsha.ac.ir/article-1-1173-en.html
Abstract:   (2430 Views)

Introduction & Objective: Nicotine could directly act as a cancer promoter. The purpose of this study was to evaluate effects of nicotine on mitotic index in esophagus epithelium.

Materials & Methods: In the present study 30 adult male mice were used. Animals were randomly divided into three groups. Group A or the control group received vehicle, groups B and C received nicotine intraperitoneally at doses of 0.2 and 0.4 mg/kg once daily for 14 days, respectively. Evaluations were made using kI-67 immunohistochemistry and Hematoxilin& Eosin for proliferative activity and morphometric study on esophagus mucosa, respectively.

Results: Administration of nicotine in group C, showed a significant increase (P<0.05) in KI-67 index 34.15±2.50vs. 10.41±1.4 compared with the control subjects.  The other parameters such as epithelial height, lamina propria, muscular mucosa and mucosa height in nicotine- treated groups were not affected. Nicotine at dose of 0.2 mg/kg did not change the mitotic index in epithelium when compared with the control group.

Conclusion: This study indicates nicotine at dose of 0.4 mg/kg increases mitotic activity in basal cells in esophagus epithelium.

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Type of Study: Original | Subject: Other Clinical Specialties

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