Volume 25, Issue 4 (Avicenna Journal of Clinical Medicine-Winter 2019)                   Avicenna J Clin Med 2019, 25(4): 185-192 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Emami F, Pakrad F, Poorolajal J, Naghshtabrizi B, Gholalikhani H R, Alizamir A. Relation of Neutrophil to Lymphocyte Ratio with Myocardial Damage in Patients Undergoing Elective Percutaneous Coronary Intervention. Avicenna J Clin Med. 2019; 25 (4) :185-192
URL: http://sjh.umsha.ac.ir/article-1-1821-en.html
1- Assistant Professor, Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- MSc in Nursing, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran , f_pakrad@yahoo.com
3- Professor, Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
4- Associate Professor, Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5- Cardiologist, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
6- Assistant Professor, Department of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract:   (2890 Views)
Background and Objective: The high ratio of neutrophils to lymphocytes is a predictor of the risk of myocardial infarction in people who have coronary artery angiography. The purpose of this study was to measure this proportion in the assessment of damage through interventions in patients with non-emergency angioplasty.
Materials and Methods: A prospective cohort study was performed on 122 patients referring to Hamadan Farshchian Heart Center, Hamadan, Iran, during 2017 for selected angioplasty. Patients were divided into two groups according to the ratio of neutrophil/ lymphocyte. Data were collected through a checklist and blood test results, including neutrophil/lymphocyte ratio, erythrocyte sedimentation rate (ESR), C-reactive Protein (CRP), Creatine kinase-MB (CKMB), and troponin before angioplasty, as well as 6 and 12 h after angioplasty. The Chi-square test and independent t-test were performed using Stata software (version 14).
Results: There was no significant difference between the ESR levels in the two groups before the angioplasty (P=0.431). However, there were significant differences between the two groups 6 h (P=0.001) and 12 h after the angioplasty (P=0.011). There was no significant difference between the blood level of troponin in both groups before (P=0.310) and 6 h after (P=0.186). However, there was a significant difference between the two groups 12 h after the angioplasty (P=0.042).
Conclusion: The results showed that an increase in the level of troponin elevated neutrophil/lymphocyte ratio and ESR. However, there was no significant difference in CRP and CKMB levels, although there were significant changes in clinical status.
Full-Text [PDF 368 kb]   (519 Downloads)    
Type of Study: Original | Subject: Cardiovascular Diseases

References
1. Mangiacapra F, Barbato E. Clinical implications of platelet-vessel interaction. J Cardiovasc Transl Res. 2013;6(3):310-5. PMID: 23271646 DOI: 10.1007/s12265-012-9441-0
2. Trotter R, Gallagher R, Donoghue J. Anxiety in patients undergoing percutaneous coronary interventions. Heart Lung. 2011;40(3):185-92. PMID: 20723986 DOI: 10.1016/j.hrtlng.2010.05.054
3. Karakas MS, Korucuk N, Tosun V, Altekin RE, Koç F, Ozbek SC, et al. Red cell distribution width and neutrophil-to-lymphocyte ratio predict left ventricular dysfunction in acute anterior ST-segment elevation myocardial infarction. J Saudi Heart Assoc. 2016;28(3):152-8. PMID: 27358532 DOI: 10.1016/j.jsha.2015.07.001
4. Verdoia M, Schaffer A, Barbieri L, Di Giovine G, Bellomo G, Marino P, et al. Impact of neutrophil-to-lymphocyte ratio on periprocedural myocardial infarction in patients undergoing non-urgent percutaneous coronary revascularisation. Neth Heart J. 2016;24(7):462-74. PMID: 27277659 DOI: 10.1007/s12471-016-0850-6
5. Brown DW, Giles WH, Croft JB. White blood cell count: an independent predictor of coronary heart disease mortality among a national cohort. J Clin Epidemiol. 2001;54(3):316-22. PMID: 11223329
6. Cho KI, Ann SH, Singh GB, Her AY, Shin ES. Combined usefulness of the platelet-to-lymphocyte ratio and the neutrophil-to-lymphocyte ratio in predicting the long-term adverse events in patients who have undergone percutaneous coronary intervention with a drug-eluting stent. PLoS One. 2015;10(7):e0133934. PMID: 26207383 DOI: 10.1371/journal.pone.0133934
7. Lee MJ, Park SD, Kwon SW, Woo SI, Lee MD, Shin SH, et al. Relation between neutrophil-to-lymphocyte ratio and index of microcirculatory resistance in patients with st-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2016;118(9):1323-8. PMID: 27600462 DOI: 10.1016/j.amjcard.2016.07.072
8. Ergelen M, Uyarel H, Altay S, Kul S, Ayhan E, Isik T, et al. Predictive value of elevated neutrophil to lymphocyte ratio in patients undergoing primary angioplasty for ST-segment elevation myocardial infarction. Clin Appl Thromb Hemost. 2014;20(4):427-32. PMID: 23314674 DOI: 10.1177/1076029612473516
9. Akpek M, Kaya MG, Lam YY, Sahin O, Elcik D, Celik T, et al. Relation of neutrophil/lymphocyte ratio to coronary flow to in-hospital major adverse cardiac events in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Am J Cardiol. 2012;110(5):621-7. PMID: 22608360 DOI: 10.1016/j.amjcard.2012.04.041
10. Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA. 1998;279(18):1477-82. PMID: 9600484
11. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the centers for disease control and prevention and the American Heart Association. Circulation. 2003;107(3):499-511. PMID: 12551878
12. Hajj-Ali R, Zareba W, Ezzeddine R, Moss AJ. Relation of the leukocyte count to recurrent cardiac events in stable patients after acute myocardial infarction. Am J Cardiol. 2001; 88(11):1221-4. PMID: 11728346
13. Poludasu S, Cavusoglu E, Khan W, Marmur JD. Neutrophil to lymphocyte ratio as a predictor of long-term mortality in African Americans undergoing percutaneous coronary intervention. Clin Cardiol. 2009;32(12):E6-10. PMID: 20014207 DOI: 10.1002/clc.20503
14. Shen XH, Chen Q, Shi Y, Li HW. Association of neutrophil/lymphocyte ratio with long-term mortality after ST elevation myocardial infarction treated with primary percutaneous coronary intervention. Chin Med J (Engl). 2010;123(23):3438-43. PMID: 22166528
15. Park JJ, Jang HJ, Oh IY, Yoon CH, Suh JW, Cho YS, et al. Prognostic value of neutrophil to lymphocyte ratio in patients presenting with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2013;111(5):636-42. PMID: 23273716 DOI: 10.1016/j.amjcard.2012.11.012
16. Soylu K, Yuksel S, Gulel O, Erbay AR, Meric M, Zengin H, et al. The relationship of coronary flow to neutrophil/lymphocyte ratio in patients undergoing primary percutaneous coronary intervention. J Thorac Dis. 2013;5(3):258-64. PMID: 23825756 DOI: 10.3978/j.issn. 2072-1439.2013.05.13
17. Sen N, Afsar B, Ozcan F, Buyukkaya E, Isleyen A, Akcay AB, et al. The neutrophil to lymphocyte ratio was associated with impaired myocardial perfusion and long term adverse outcome in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Atherosclerosis. 2013;228(1):203-10. PMID: 23489347 DOI: 10.1016/j.atherosclerosis.2013.02.017
18. Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J. 2007;154(5):995-1002. PMID: 17967611 DOI: 10.1016/j.ahj.2007.06.043
19. Wang X, Zhang G, Jiang X, Zhu H, Lu Z, Xu L. Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies. Atherosclerosis. 2014;234(1):206-13. PMID: 24681815 DOI: 10.1016/j.atherosclerosis.2014.03.003
20. Dong CH, Wang ZM, Chen SY. Neutrophil to lymphocyte ratio predict mortality and major adverse cardiac events in acute coronary syndrome: a systematic review and meta-analysis. Clin Biochem. 2018;52:131-6. PMID: 29132766 DOI: 10.1016/j.clinbiochem.2017.11.008
21. Fowler AJ, Agha RA. Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography--the growing versatility of NLR. Atherosclerosis. 2013;228(1):44-5. PMID: 23474126 DOI: 10.1016/j.atherosclerosis.2013.02.008
22. Nakazawa KR, Wengerter SP, Power JR, Lookstein RA, Tadros RO, Ting W, et al. Preoperative inflammatory status as a predictor of primary patency after femoropopliteal stent implantation. J Vasc Surg. 2017;66(1):151-9. PMID: 28259571 DOI: 10.1016/j.jvs.2017.01.031
23. Soylu K, Gedikli O, Dagasan G, Aydin E, Aksan G, Nar G, et al. Neutrophil-to-lymphocyte ratio predicts coronary artery lesion complexity and mortality after non-ST-segment elevation acute coronary syndrome. Rev Port Cardiol. 2015;34(7-8):465-71. PMID: 26164277 DOI: 10.1016/j. repc.2015.01.013
24. Montecucco F, Liberale L, Bonaventura A, Vecchiè A, Dallegri F, Carbone F. The role of inflammation in cardiovascular outcome. Curr Atheroscler Rep. 2017; 19(3):11. PMID: 28194569 DOI: 10.1007/s11883-017-0646-1
25. Göktaş MU, Akyol PY, Karakaya Z, Payza U, Topal FE. Evaluation of white blood cell and neutrophil/lymphocyte ratio in acute coronary syndrome patients admitted to emergency department. Biomed Res. 2018;29(10):2009-14.
26. Bogaty P, Boyer L, Simard S, Dauwe F, Dupuis R, Verret B, et al. Clinical utility of c-reactive protein measured at admission, hospital discharge, and 1 month later to predict outcome in patients with acute coronary disease: the risca (recurrence and inflammation in the acute coronary syndromes) study. J Am Coll Cardiol. 2008;51(24):2339-46. PMID: 18549920 DOI: 10.1016/j.jacc.2008.03.019

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2021 All Rights Reserved | Avicenna Journal of Clinical Medicine

Designed & Developed by : Yektaweb