Volume 28, Issue 2 (Avicenna Journal of Clinical Medicine-Summer 2021)                   Avicenna J Clin Med 2021, 28(2): 118-125 | Back to browse issues page

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Yousefian M, Angaji S A, Siasi E, Rahmani S A, Abbasalizadeh Khiaban S. Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women. Avicenna J Clin Med 2021; 28 (2) :118-125
URL: http://sjh.umsha.ac.ir/article-1-2252-en.html
1- PhD Candidate, Department of Genetics, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
2- Associate Professor, Department of Cell and Molecular Biology, School of Biological Sciences, Kharazmi University, Tehran, Iran , Angaji@khu.ac.ir
3- Assistant Professor, Department of Genetics, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
4- Assistant Professor, Department of Medical Genetics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5- Professor, Department of Obstetrics & Gynecology, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:   (1877 Views)
Background and Objective: The mutation of F2 and PAI-1 genes can cause thrombophilia in women. The present study aimed to assess the relationship of recurrent pregnancy loss (RPL) with rs3136520 in F2 and rs6090 in PAI-1.
Materials and Methods: This case-control study was conducted on 120 women with idiopathic RPL as case group and 120 healthy women without any history of infertility or abortion with at least one healthy child as the control group. These subjects were referred to a private genetic lab by a gynecologist. Both polymorphisms were studied using the amplification-refractory mutation system-polymerase chain reaction approach, and the obtained data were analyzed in SPSS software (version 26) using the chi-squared test (P˂0.05).
Results: In the multiplicative model, there was a significant association between rs6090 and RPL (OR=0.222; 95%CI=0.082-0.599); nonetheless,
no relationship was detected between rs3136520 and RPL (OR=1, 95%CI=0.488-2.049). Moreover, according to additive model, there was no association between rs3136520 and RPL; however, there was a significant relationship between AG genotype in rs6090 and RPL (OR=0.245; 95% CI=0.066-0.901).
Conclusion: As evidenced by the obtained results, there was a protective association between rs6090 and RPL; nonetheless, there was no relationship between rs3136520 and RPL.
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Type of Study: Original | Subject: Genetics

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