Volume 30, Issue 2 (Avicenna Journal of Clinical Medicine-Summer 2023)
Avicenna J Clin Med 2023, 30(2): 72-80 |
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Teimouri K, Khoshgard K, Farshchian N, Rouzbahani M, Azimivaghar J, Sharafi N. Investigating the Radiation Dose Received by the Heart and Its Electrocardiographic Changes after Three-dimensional Conformal Radiation Therapy in Patients with Left Breast Cancer. Avicenna J Clin Med 2023; 30 (2) :72-80
URL: http://sjh.umsha.ac.ir/article-1-2718-en.html
URL: http://sjh.umsha.ac.ir/article-1-2718-en.html
Kolsoum Teimouri1 
, Karim Khoshgard 2, Negin Farshchian3 , Mohammad Rouzbahani4 , Javad Azimivaghar4 , Nasrin Sharafi5
, Karim Khoshgard 2, Negin Farshchian3 , Mohammad Rouzbahani4 , Javad Azimivaghar4 , Nasrin Sharafi5
1- Department of Medical Physics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Department of Medical Physics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran , khoshgardk@gmail.com
3- Department of Radiation Oncology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4- Department of Cardiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
5- Radiation Oncology Ward, Imam Raza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Department of Medical Physics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran , khoshgardk@gmail.com
3- Department of Radiation Oncology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4- Department of Cardiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
5- Radiation Oncology Ward, Imam Raza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract: (740 Views)
Background and Objective: Breast cancer is one of the most common cancers and the fifth leading cause of cancer deaths in Iran. The present study aimed to investigate the absorbed dose received by the heart and its relationship with cardiac complications in radiotherapy of patients with left breast cancer using a three-dimensional conformal radiotherapy technique.
Materials and Methods: A total of 181 women with left breast cancer who received radiotherapy after surgery were included in the study. Dosimetric parameters were obtained using dose-volume histograms for the heart, whole lung, left lung, and clinical target volume. Electrocardiography tests were performed for all patients before and one year after the radiotherapy.
Results: The mean doses of heart, left lung, whole lung, and clinical target volume were 6.3±3.1, 13.3±4.5, 6.9±3.7, and 47.3±6.4 Gray (Gy), respectively. A significant reduction in T-wave amplitude was observed in 57% of patients three months after radiotherapy. T-wave amplitude decreased from 3.03±0.92 mm to 1.56±0.83 mm. The reduction in the T-wave amplitude displayed a significant relationship with the mean dose of the heart (β = 2.653; P= 0.019).
Conclusion: In women with left-sided breast cancer, cardiac complications are frequent, for which electrocardiographic tests can be used for cardiac evaluation after radiotherapy. Based on the obtained results, the most frequent side effect caused by radiotherapy in these patients was an abnormality in T-wave
Materials and Methods: A total of 181 women with left breast cancer who received radiotherapy after surgery were included in the study. Dosimetric parameters were obtained using dose-volume histograms for the heart, whole lung, left lung, and clinical target volume. Electrocardiography tests were performed for all patients before and one year after the radiotherapy.
Results: The mean doses of heart, left lung, whole lung, and clinical target volume were 6.3±3.1, 13.3±4.5, 6.9±3.7, and 47.3±6.4 Gray (Gy), respectively. A significant reduction in T-wave amplitude was observed in 57% of patients three months after radiotherapy. T-wave amplitude decreased from 3.03±0.92 mm to 1.56±0.83 mm. The reduction in the T-wave amplitude displayed a significant relationship with the mean dose of the heart (β = 2.653; P= 0.019).
Conclusion: In women with left-sided breast cancer, cardiac complications are frequent, for which electrocardiographic tests can be used for cardiac evaluation after radiotherapy. Based on the obtained results, the most frequent side effect caused by radiotherapy in these patients was an abnormality in T-wave
Type of Study: Original |
Subject:
Radiotherapy
Extended Abstract [HTML 34 KB] (59 Download)
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