Volume 10, Issue 3 (Scientific Journal of Hamadan University of Medical Sciences-Autumn 2003)                   Avicenna J Clin Med 2003, 10(3): 39-42 | Back to browse issues page

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Zeraati F, Malakoti S M, Araghchian M, Sheikh N, Nadi E. Comparison of Inhibitory Effect of Gripe Mixture and Caraway Mixture on Acetylcholine Induced Spasm in Rat jejunum. Avicenna J Clin Med. 2003; 10 (3) :39-42
URL: http://sjh.umsha.ac.ir/article-1-657-en.html
Abstract:   (3751 Views)

In comparison of effects of various drugs with the same indications produced by different companies or comparing drugs manufactured in Iran with their foreign counterparts may result in producing drugs with higher qualities in our country. In this study the spasmolithic effect of two herbal drugs , gripe mixture and caraway mixture , that are prescribed as spasmolithic and carminative in infants were compared.

          2 cm of rat jejunum was placed in a organ bath containing tyrode solution (37 C° , 100% O2) . The jejunum was contracted because of acetylcholine (1mml). when the muscle contraction reached the plateau  the different volumes of drug were added to the organ bath. The inhibitory effect of drug indicated by physiograph , the intestine was washed two times. When the intestine reached the basal tonicity , the different volumes
   of second drug were tested. The results were compared using paired t.test .

The results show that both drugs inhibit the spasm induced by
   acetylcholine in rat jejunum . This inhibitory effect was dose dependent. The caraway mixture showed a higher effect in comparison with gripe mixture (P<0.05).

          The caraway mixture has a higher inhibitory effect on acetylcholine
   induced spasm in rat jejunum . It seems that it has the same effect on
   human.

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Type of Study: Original | Subject: Other Clinical Specialties

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