Alpha-1-AntiTrypsin (α1–AT) is an inhibitory α1–Protease, and belongs to
   complex protein of glycoprotein  type. From the activity point of view, it 
   belongs to Seiren protease inhibitors ( serpin ).There are many reports in
   litreture concerning a decrease in the amount of α1-AT in patients with
   emphysema, skin  disorders, adult liver disease, hypothyroidism,and so on .
   In hypothyroidic patients along with a decrease in the amount of T3 , there
   is a significant decrease in the amount of α1– AT and  consequently in the
   amount of TIC.Therefore , it can be expected that , in hyperthyroidic an
   increase in the amount of T3 results in an increase in the amounts of α1– AT
   and TIC.

          In this study , changes in TIC in hyperthyroidic  patients  in comparison
   with a control group was  investigated. Measurements were performed on
   72  samples , and by  using T- test and determination of correlation
   coeffiecint,the above mentioned changes were analyzed .

          The results showed that TIC in hyperthyroidic patients ( n= 42 ) had
   increased in comparison  with the control group ( n = 30 ),

   ( n = 42 , TIC = 2.54 ± 0.414 mg/ml    Vs    n= 30 ,TIC= 1.87 ± 0.29 mg/ml). It was
   observed that in hyperthyroidic  patients, there is a positive correlation
   between the amounts of T3 and TIC ( r = 0.71 , p < 0.0001).

          Therefore, it can be concluded that trypsin inhibitory capacity and
   &alpha;1- AT concentration had increased in hyperthyroidic patients.