This cross-sectional   descriptive   analytic   study  was  carried   out  for

    evaluation of posttransfusion infections (Hepatitis B,C and Aids) in children

    suffering major thalassemia who were transfused repeatedly. The  relation

    of liver inflammation and number of blood transfusions were studied.

          A check list was completed for each case. ALT, HBsAg , anti-HCV  and

    anti-HIV tests were preformed for all of 53 children. Population were  fifthy

    three   major   thalasemic   children   under   15   years   old  in   Hamadan

    provience.

          Twenty two  out of  53 children (41.5%) had  elevated  ALT, 18  patients

    (34%) had positive anti-HCV. In all of 18 patients with positive anti-HCV,ALT

    was also  elevated  , all  of the patients were negative for anti-HBsAg and

    anti-HIV.

          Determination of ALT level of the donated blood is useful for detection

    of chronic hepatitis. This test can be used as an easy screening tool.