The extensive use of tricyclic antidepression drugs, the approximation of the therapeutic levels of the drugs to toxic level and the availability of the drugs to depressed patients who have potentially the idea of committing suicide has made these drugs one of the most popular drugs for the patients who commit suicide in a retrospective study on 24 patients in Sina Medical Center in Hamadan. We came to this conclusion that prompt transfer of the patients and gastric lavage the most important way of the management. Concerning the fast absorption of the drug from G.I. tract and the direct relation between E.K.G. changes and plasma level of the drug, we can use the E.K.G. changes as a criterion to estimate the level of plasma augmentation to toxic levels and also we can surely discharge the patients if there is no E.K.G. changes and the patient is quite conscious.