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Showing 2 results for Dextromethorphan
Dextromethorphan Reduces Postoperative Pain of Post Partum Tubal Ligation under General Anesthesia
Nahid Manochehrian, Seyyed Majid Hashemi Fesharaki, Pooran Hajian, Ebrahim Khoshraftar,
Volume 16, Issue 1 (6-2009)
Abstract

Introduction & Objective: Postoperative pain has harmful effects in many systems. Dextromethorphan reduces postoperative pain in post partum tubal ligation under general anesthesia.

Materials & Methods: In this research 40 patients with ASA class I and II in double blind randomized clinical trial were studied in two groups. 90 minutes before surgery the patients received 90 mg dextromethorphan or placebo (oral). The patients induced general anesthesia with thiopental (5mg/kg), fentanyl 1.5 mg/kg and succinylcholine (1-1.5 mg/kg) and maintenance with halothane and N2O 50%. Patients were observed studied for analgesic requirement, nausea, vomiting, urinary retention and respiratory depression in recovery and 2,4,8 and 24 hours after surgery.

Results: There was no significant difference in age, education, . . . Pain in recovery, 2 and 4 hours after surgery in dextromethorphan was less than placebo group. The analgesic requirement (pethidine) in dextromethophan was less than placebo group.

Conclusion: Administration of 90 mg dextromethorphan 90 minutes before the surgery under GA reduces pain in recovery time , 2 and 4 hours after the surgery.


Effect of 30 mg Oral Dextromethorphan and Placebo on Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy
Mahmoud Rezaei, Leila Sarabi, Seyed Mohammad Zolhavarieh, Ghodratollah Roshanaei,
Volume 30, Issue 1 (6-2023)
Abstract
Background and Objective: Laparoscopic cholecystectomy is considered a global standard procedure for the surgical treatment of gallstones. The present study aimed to compare the effect of dextromethorphan and oral placebo on postoperative analgesia in patients undergoing laparoscopic cholecystectomy.
Materials and Methods: This double-blind clinical trial study was performed on 114 ASA I and II patients who were candidates for laparoscopic cholecystectomy. Two hours before the induction of anesthesia, the intervention group was administered 30 mg of plain dextromethorphan syrup, and the control group was given 2 cc of placebo of an oral syrup. Pain intensity, systolic and diastolic blood pressure, heart rate, and SPO2 at the time of recovery, 1, 6, and 12 hours after surgery, and the amount of pethidine were recorded. Data were analyzed in SPSS software (version 24) at a significance level of 0.05.
Results: The mean pain intensity was statistically significant in the control and intervention groups. The mean pain intensity in the intervention group was lower than that in the control group (P<0.05). Diastole blood pressure, heart rate, and SPO2 in the two groups did not have a statistically significant difference (P>0.05), while systolic blood pressure statistically differed (P<0.05). The amount of pethidine consumption in the intervention group was higher than that in the control group.
Conclusion: As evidenced by the obtained results, low-dose dextromethorphan (30 mg) is effective in postoperative analgesia for patients undergoing laparoscopic cholecys-tectomy and reduces opioid use.

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