Volume 29, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2022)
Avicenna J Clin Med 2022, 29(1): 5-11 |
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Farahani Z, Farahani F, Ranjbar A, Shariatpanahi E, Mohammadi Y, Emami S F. Effect of Nanocurcumin on Tinnitus. Avicenna J Clin Med 2022; 29 (1) :5-11
URL: http://sjh.umsha.ac.ir/article-1-2274-en.html
URL: http://sjh.umsha.ac.ir/article-1-2274-en.html
Zahra Farahani1 
, Farhad Farahani2 , Akram Ranjbar3 , Elnaz Shariatpanahi2 , Younes Mohammadi4 , Seyede Farank Emami 5
, Farhad Farahani2 , Akram Ranjbar3 , Elnaz Shariatpanahi2 , Younes Mohammadi4 , Seyede Farank Emami 5
1- Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of ENT, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Audiology, School of Rehabilitation, Hamadan University of Medical Sciences, Hamadan, Iran ,faranak_imami@yahoo.com
2- Department of ENT, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Audiology, School of Rehabilitation, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract: (4231 Views)
Background and Objective: Oxidative stress is one of the causes of tinnitus. The therapeutic effect of nanocurcumin on the antioxidant processes of various diseases has been confirmed; however, no study, to the best of our knowledge, has been conducted on its therapeutic effect on tinnitus. Therefore, the present study aimed to determine the effect of nanocurcumin on treating tinnitus.
Materials and Methods: This study was a randomized controlled trial (triple-blind intervention). A total of 62 patients with tinnitus were selected by randomized block design with observance of concealment. Then, the participants were divided into two groups of 31 and were treated with nanocurcumin and a placebo. Both groups were similar in terms of age and gender with frequency matching methods. Hearing tests were performed for all patients. Patients received 80 mg/day of nanocurcumin and similar placebo capsules for 21 days.
Results: The mean and standard deviation of the age in the nanocurcumin and placebo groups were 44.77 ± 15.2 and 46.32 ± 15.2 years, respectively (P>0.05). The difference between the mean duration of tinnitus was not significant in both groups (P>0.05). The results indicated that the antioxidant nanocurcumin reduced the tinnitus score (P=0.02). However, nanocurcumin failed to affect the frequency, high score, degree of annoyance, mean score of speech discrimination, and speech reception threshold (P>0.05). Also, no side effect was reported from using nanocurcumin.
Conclusion: Nanocurcumin is not effective in the treatment of tinnitus.
Materials and Methods: This study was a randomized controlled trial (triple-blind intervention). A total of 62 patients with tinnitus were selected by randomized block design with observance of concealment. Then, the participants were divided into two groups of 31 and were treated with nanocurcumin and a placebo. Both groups were similar in terms of age and gender with frequency matching methods. Hearing tests were performed for all patients. Patients received 80 mg/day of nanocurcumin and similar placebo capsules for 21 days.
Results: The mean and standard deviation of the age in the nanocurcumin and placebo groups were 44.77 ± 15.2 and 46.32 ± 15.2 years, respectively (P>0.05). The difference between the mean duration of tinnitus was not significant in both groups (P>0.05). The results indicated that the antioxidant nanocurcumin reduced the tinnitus score (P=0.02). However, nanocurcumin failed to affect the frequency, high score, degree of annoyance, mean score of speech discrimination, and speech reception threshold (P>0.05). Also, no side effect was reported from using nanocurcumin.
Conclusion: Nanocurcumin is not effective in the treatment of tinnitus.
Type of Study: Original |
Subject:
Otorhinolaryngology
Extended Abstract [HTML 26 KB] (174 Download)
References
1. Baeuer CB. Otolaryngology head and neck surgery. 3rd ed. Philadelphia: Mosby; 2010.
3. Haase GM, Prasad KN, Cole WC, Baggett-Strehlau JM, Wyatt SE. Antioxidant micronutrient impact on hearing disorders: concept, rationale, and evidence. Am J Otolaringol. 2011;32(1):55-61. [DOI] [PubMed]
4. Goldstein BA, Shulman A, Lenhar ML, Richards DG, Madsen AG, Guinta R. Long-term inhibition of tinnitus by ultra quiet therapy: preliminary report. Int Tinnitus J. 2001;7(1):122-7. [PubMed]
5. Pan JS, Hong MZ, Ren JL. Reactive oxygen species: a double-edged sword in oncogenesis. World J Gastroenterol. 2009;15:1702-7. [DOI] [PubMed]
6. Ruan RS. Possible roles of nitric oxide in the physiology and pathophysiology of the mammalian cochlea. Ann N Y Acad Sci. 2002;962:260-74. [DOI] [PubMed]
7. Sha SH, Taylor R, Forge A, Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res. 2001;155(1-2):1-8. [DOI] [PubMed]
8. Sha SH, Chen FQ, Schacht J. Activation of cell death pathways in the inner ear of the aging CBA/J mouse. Hear Res. 2009;254(1-2):92-9. [DOI] [PubMed]
9. Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neuro-degenerative disease: A recent update. Food Chem Toxicol. 2015;83:111-24. [DOI] [PubMed]
10. Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 2009;30:85-94. [DOI] [PubMed]
11. Schraufstatter E, Bernt H. Antibacterial action of curcumin and related compounds. Nature. 1949;164(4167):456. [DOI] [PubMed]
12. H Hatcher H, Planalp R, Cho J, Torti F M, Torti S V. Curcumin: From ancient medicine to current clinical trials. Cell Mol Life Sci. 2008;65(11):1631-52. [DOI] [PubMed]
13. Shishodia S, Sethi G, Aggarwal BB. Curcumin: Getting back to the roots. Ann N Y Acad Sci. 2005;1056:206-17. [DOI] [PubMed]
14. Huang MT, Lysz T, Ferraro, T, Abidi T F, Laskin J D, Conney AH. Inhibitory effects of curcumin on invitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 1991;51(3):813-9. [PubMed]
15. Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012;39(3):283-99. [DOI] [PubMed]
16. Epelbaum R, Schaffer M, Vizel B, Badmaev V, Bar-Sela G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer. 2010;62(8):1137-41. [DOI] [PubMed]
17. Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013;1(1):448-56. [DOI] [PubMed]
18. Chatterjee A, Debnath K, Hanumanta Rao NK. A comparative evaluation of the efficacy of curcumin and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A double-blinded randomized controlled clinical study. J Indian Soc Periodontol. 2017;21(2):132-7. [DOI] [PubMed]
19. Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB. Multitargeting by turmeric, the golden spice: From kitchen to clinic. Mol Nutr Food Res. 2013;57(9):1510-28. [DOI] [PubMed]
20. Mahmoudian S, Shahmiri E, Rouzbahani M, Jafari Z, Keyhani M, Rahimi F, et al. Persian language version of the tinnitus handicap inventory: translation, standardization, validity and reliability. Int Tinnitus J. 2011;16(2):93-103. [PubMed]
21. Emerit J, Edeas M, Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother. 2004;58(1):39-46. [DOI] [PubMed]
22. White CM, Pasupuleti V, Roman YM, Li Y, Hernandez VH. Oral turmeric/curcumin effects on inflammatory markers in chronic inflammatory diseases: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2019;146:104280. [DOI] [PubMed]
23. Unlu A, Nayir E, Kalenderoglu MD, Kirca O, Ozdogan M. Curcumin (Turmeric) and cancer. J BUON. 2016;21(5):1050-1060. [PubMed]
24. Haryuna TSH, Riawan W, Nasution A, Ma'at S, Harahap J, Adriztina I. Curcumin Reduces the Noise-Exposed Cochlear Fibroblasts Apoptosis. Int Arch Otorhinolaryngol. 2016;20(4):370–376. [DOI] [PubMed]
25. Yamaguchi T, Yoneyama M, Masanori, Onaka Y, Yusuke, Imaizumi A, Atsushi & Ogita, K. Preventive effect of curcumin and it's highly bioavailable preparation on hearing loss induced by single or repeated exposure to noise: A comparative and mechanistic study. J Pharmacol Sci. 2017;134(4):225-233. [DOI]
26. Adalier N, Parker H. Vitamin E, Turmeric and saffron in treatment of alzheimer's disease. Antioxidants (Basel). 2016;5(4):40-46. [DOI] [PubMed]
27. Pall ML, Bedient SA. The NO/ONOO- cycle as the etiological mechanism of tinnitus. Int Tinnitus J. 2007;13(2):99-104. [PubMed]
28. Tziridis K KS, Ahlf S, Schulze H. Protective effects of ginkgo biloba extract egb 761 against noise trauma-induced hearing loss and tinnitus development. Neural Plast. 2014;2014:427298. [DOI] [PubMed]
29. Scasso F, Sprio AE, Canobbio L, Scanarotti C, Manini G, Berta GN, Bassi AN. Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study. Heliyon. 2017;3(2):e00251. [PubMed]
30. Stano M, Brescia G, Marioni G. Antioxidant therapy in idiopathic tinnitus: preliminary preliminary outcomes. Arch Med Res. 2007;38(4):456-9. [PubMed]
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