Volume 30, Issue 4 (Avicenna Journal of Clinical Medicine-Winter 2024)                   Avicenna J Clin Med 2024, 30(4): 233-239 | Back to browse issues page


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Hadei S K, Abarvazn E. Exploring the Complex Interplay: Fatty Liver Severity, Epicardial Fat Volume, and Coronary Artery Calcification. Avicenna J Clin Med 2024; 30 (4) :233-239
URL: http://sjh.umsha.ac.ir/article-1-2870-en.html
1- Department of Radiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Radiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , dr.eghbalabarvazn@gmail.com
Abstract:   (213 Views)
Background and Objective: Cardiovascular diseases and nonalcoholic fatty liver disease are the most common non-communicable diseases in most developed countries, and due to lifestyle changes, their incidence is increasing day by day. The present study aimed to assess the correlation of fatty liver with epicardial fat volume and coronary artery calcium score.
Materials and Methods: This cross-sectional study was conducted on 136 patients referred to Hamadan Farshchian Cardiovascular Hospital for computed tomography (CT) angiography. They were selected using a consecutive sampling method. Using a 128-slice multidetector CT scanner, the coronary artery calcium score based on the Agatston criteria and epicardial fat volume were measured. A liver ultrasound was performed using a GE voluson E6 and a 3-5 MHz depth probe, and the severity of the fatty liver was determined based on the echogenicity of the liver on the ultrasound. Data analysis was conducted using the SPSS software (version 26).
Results: The mean age scores of patients were 52.90±12.10 years. Regarding gender, 50.5% and 49.5% of cases were male and female, respectively. In terms of fatty liver grade, 64 (47.1%), 48 (35.3%), 21 (15.4%), and 3 (2.2%) cases had grades zero, I, II, and III, respectively. The mean calcium score was 30.76±35.40, and epicardial fat volume was 86.84±36.56. The severity of fatty liver demonstrated no significant relationship with calcium score and epicardial fat (P>0.05).
Conclusion: As evidenced by the obtained results, the severity of fatty liver had no relationship with the amount of coronary epicardial fat and coronary artery calcium.
 
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Type of Study: Original | Subject: Liver & Digestive Diseases

References
1. Harte AL, da Silva NF, Creely SJ, McGee KC, Billyard T, Youssef-Elabd EM, et al. Elevated endotoxin levels in nonalcoholic fatty liver disease. J Inflamm. 2010;7:15. PMID: 20353583 DOI: 10.1186/1476-9255-7-15
2. Bellentani S, Scaglioni F, Marino M, Bedogni G. Epidemiology of nonalcoholic fatty liver disease. Dig Dis. 2010;28(1):155-61. PMID: 20460905 DOI: 10.1159/000282080
3. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43(S1):S99-S112. DOI: 10.1159/000282080
4. Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease—meta‐analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73-84. PMID: 26707365 DOI: 10.1002/hep.28431
5. Salehisahlabadi A, Jadid H. The Prevalence of Nonalcoholic Fatty Liver Disease in Iranian Children and Adolescents: A Systematic Review and Meta-Analysis. JSUMS. 2018;25(4):487-94.
6. Maki Z, Sadeghi Sedeh B, Fazeli Moslehabadi M. Prevalence of fatty liver in sonographic findings of patients referred to sonoxafi centers in Arak in 2014. Arak Medical University of Science. 2015.
7. Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology. 1999;116(6):1413-9. PMID: 10348825 DOI: 10.1016/s0016-5085(99)70506-8
8. Kirovski G, Schacherer D, Wobser H, Huber H, Niessen C, Beer C, et al. Prevalence of ultrasound-diagnosed nonalcoholic fatty liver disease in a hospital cohort and its association with anthropometric, biochemical and sonographic characteristics. Int J Clin Exp Med. 2010;3(3):202-10. PMID: 20827318
9. Bellentani S, Marino M. Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD). Ann Hepatol. 2009;8(1):S4-8. PMID: 19381118
10. Wylde V, Beswick A, Bruce J, Blom A, Howells N, Gooberman-Hill R. Chronic pain after total knee replacement. EFORT Open Rev. 2018;3(8):461-70. PMID: 30237904 DOI: 10.1302/2058-5241.3.180004
11. Antony AB, Schultheis BC, Jolly SM, Bates D, Hunter CW, Levy RM. Neuromodulation of the dorsal root ganglion for chronic postsurgical pain. Pain Med. 2019;20(1):S41-S6. PMID: 31152174 DOI: 10.1093/pm/pnz072
12. Hunter CW, Deer TR, Jones MR, Chang Chien GC, D’Souza RS, Davis T, et al. Consensus Guidelines on Interventional Therapies for Knee Pain (STEP Guidelines) from the American Society of Pain and Neuroscience. J Pain Res. 2022;15:2683-745. PMID: 36132996 DOI: 10.2147/JPR.S370469
13. Fakharian T, Heydari S, Azarkar G. The role of nonalcoholic fatty liver disease (NAFLD) in the occurrence of CVDs through measuring carotid intima-media thickness. J Birjand Univ Med.2017; 24(1):63-72.
14. Juottonen K, Gockel M, Silén T, Hurri H, Hari R, Forss N. Altered central sensorimotor processing in patients with complex regional pain syndrome. Pain. 2002;98(3):315-23. PMID: 12127033 DOI: 10.1016/S0304-3959(02)00119-7
15. Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine. 2020;29-30:100587. PMID: 34505846 DOI: 10.1016/j.eclinm.2020.100587
16. Macatangay M, Buensalido J. 69: comparing the outcomes of giving tocilizumab then hemoperfusion, hemoperfusion then tocilizumab, and no intervention in critical sars-cov-2 pneumonia patients in makati medical center. J Glob Antimicrob Resist. 2022;31:S39. DOI: 10.1016/S2213-7165(22)00348-4
17. Darazam IA, Kazempour M, Pourhoseingholi MA, Hatami F, Rabiei MM, Gharehbagh FJ, et al. Efficacy of Hemoperfusion in Severe and Critical Cases of COVID-19. Blood Purif. 2023;52(1):8-16. PMID: 35580567 DOI: 10.1159/000524606
18. Vardanjani AE, Ronco C, Rafiei H, Golitaleb M, Pishvaei MH, Mohammadi M. Early hemoperfusion for cytokine removal may contribute to prevention of intubation in patients infected with COVID-19. Blood Purif. 2021;50(2):257-60. PMID: 32594085 DOI: 10.1159/000509107
19. Draghi F, Ferrozzi G, Urciuoli L, Bortolotto C, Bianchi S. Hoffa’s fat pad abnormalities, knee pain and magnetic resonance imaging in daily practice. Insights Imaging. 2016;7(3):373-83. PMID: 27000624 DOI: 10.1007/s13244-016-0483-8
20. Tahmasebi M. Evaluation of the relationship between diffuse fat infiltration rate in the liver and coronary artery calcification rate in patients referred to CT angiography ward of Shahid Modares Hospital per year2015. Shahid Beheshti Univ Med Sci J.2015:20-28.
21. Lund NF, Cohen SA, Scarles C. The power of social media storytelling in destination branding. JDMM . 2018;8:271-80. DOI: 10.1016/j.jdmm.2017.05.003
22. Thomas D, Bush K, Prentice R, Ramsey B, Paredes A, Aden JK, et al. Severity of biopsy proven NAFLD not predictive of presence or severity of coronary atherosclerosis in asymptomatic patients: results from the prospective revelance study. J Am Coll Cardiol.2018; 71(11S):A1901-A.
23. Chhabra R, O’Keefe JH, Patil H, O’Keefe E, Thompson RC, Ansari S, Kennedy KF, Lee LW, Helzberg JH. Association of coronary artery calcification with hepatic steatosis in asymptomatic individuals. InMayo Clinic Proceedings. 2013;88(11):1259-56. DOI: 10.1016/j.mayocp.2013.06.025
24. Kim D, Park EH, Kim W, Choi SY, Kim YJ, Yoon JH, et al. 349 NON-Alcolic fatty liver disease and coronary artery clacification score by multy detector computed tomoraphy; Cross Sectional Case Control stydy frome health centers work. Hepatology. (2010; 52):S145-S6.
25. Turan Y. The nonalcoholic fatty liver disease fibrosis score is related to epicardial fat thickness and complexity of coronary artery disease. Angiology.2020; 71(1):77-82. DOI: 10.1177/0003319719844933
26. Meng X, Wang W, Zhang K, Qi Y, An S, Wang S, et al. Epicardial adipose tissue volume is associated with nonalcoholic fatty liver disease and cardiovascular risk factors in the general population. Ther Clin Risk Manag.2018;14: 1499-506. PMID: 30197519 DOI: 10.2147/TCRM.S168345
27. Radu F, Potcovaru C-G, Salmen T, Filip PV, Pop C, Fierbințeanu-Braticievici C. The Link between NAFLD and Metabolic Syndrome. Diagnostics. 2023;13(4):614. PMID: 36832102 DOI: 10.3390/diagnostics13040614

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