Introduction : There are several introduced forms of treatment for patients with relapse-remitting & secondary progressive multiple sclerosis in recent years. Interferon beta-1b (Betaferon) is the first of these agents that administered subcutaneously once in every two days.

Case Report: This report is related to a 33 years old female. After 6 times of Betaferon injection vasculitis necrotizing was occurred with perforated ulcer (3´3.5 cm) on the Lt side prox. lower limb . Simultaneoulsly ulcer (0.5´0.5 cm) on the Lt side prox. upper limb , small ulcer (1´1 cm) on the Rt side prox. lower limb and erythemia on the Rt side prox. upper limb around injection site.

Conclusion: Betaferon was stopped to ensure ulcers is healed. The patient showed improvement after 3 months without debridment. It is recommended to proceed with the above plan until complete recovery is achieved.