Substance use disorder is the second most common psychiatric disorders and is far more prevalent among young adults (ages;18-34y/0). Because of its importance and main effect in society, this study performed for evaluation of association fourteen childhood and adoleseence pathologic factors with substance use disorder among a group of abuser (20-30/0)that referred to five addiction center in Tehran .

          The sample consist 100 patient: including 50 case and 50 control who were selected by DSM- IV based semi-structured diagnostic interviews for decrease memory biases in this retrospective cohart study. The patient’s parents also evaluated by DSM- IV based Semi-structured diagnostic interviews.

          The analysis showed significant relation between: parents control on the siblings, addiction in relatives of pt (except parents), addicted peers and friends, to be affected with the peers and friends and substance use disorder at the ages (20-30y/o). There wasn’t any association between:
   Disruptive childhood behaviors (under 11y/o), diagnosed medical illness (under 11y/o) diagnosed Psychiatric illness (under <11y/o ) , physical and psychological abuse, Divorce and separation of one parents (>6 mo) , family size, socio economic state and substance use disorder at the age(20-30y/0 ).

          Finally some childhood and adolescence pathologic factors has association with Substance use disorder at the ages ( 20-30y/5) that these can be used for education all planning , prevention , design high risk group and remedical plans.