Volume 26, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2019)
Avicenna J Clin Med 2019, 26(1): 5-11 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Nasrabadi Z, Rakhshani M H, Ebadi H, Akbarzadeh R. Comparison of the Effect of Gabapentin and Evening Primrose Oil on Peripheral Neuropathy Pain in Patients with Type 2 Diabetes. Avicenna J Clin Med 2019; 26 (1) :5-11
URL: http://sjh.umsha.ac.ir/article-1-1861-en.html
URL: http://sjh.umsha.ac.ir/article-1-1861-en.html
1- , roakbarzadeh53@gmail.com
Abstract: (7262 Views)
Background and Objective: Neuropathic pain is one of the common, important, and irritating complications in diabetes. Despite the importance of this pain, there is still no effective treatment for that. The aim of this study was to determine the effect of evening primrose oil and gabapentin on neuropathic pain in patients with type 2 diabetes.
Materials and Methods: This triple-blind clinical trial was performed on 70 patients with diabetic neuropathy who obtained score 2 from the Michigan Questionnaire and referred to the Department of Endocrinology at Khayyam clinic affiliated to Hakim Hospital in Neyshabour from December 2017 to May 2018. The participants were divided into two groups of 35 people. The intervention group was treated with a capsule of evening primrose oil orally (1000 mg) twice daily for three months and gabapentin (300 mg) daily. On the other hand, the control group was treated with gabapentin (300 mg) and placebo. The neuropathy pain severity was measured before and after the end of three-month intervention using Michigan and McGill Pain Questionnaires. Data analysis was performed in SPSS software (version 21) through Fisher's exact test, ANCOVA, multilevel logistic regression, Mann Whitney U test, Kolmogorov-Smirnov test, and the Chi-square tests. P-value less than 0.05 was considered statistically significant.
Results: According to the results obtained from the McGill questionnaire, the mean scores of neuropathy before the intervention were obtained at 10.12±0.57 and 9.85±0.65 in the intervention and control groups, respectively. However, the mean scores of neuropathy after the intervention were estimated at 6.18±0.48 and 8.31±0.60 in the intervention and control groups, respectively, which was statistically significant (P<0.02).
Conclusion: Evening primrose oil is effective in reducing neuropathic pain in type 2 diabetic patients. Therefore, this can be a supplementary treatment for reducing pain associated with diabetic neuropathy.
Materials and Methods: This triple-blind clinical trial was performed on 70 patients with diabetic neuropathy who obtained score 2 from the Michigan Questionnaire and referred to the Department of Endocrinology at Khayyam clinic affiliated to Hakim Hospital in Neyshabour from December 2017 to May 2018. The participants were divided into two groups of 35 people. The intervention group was treated with a capsule of evening primrose oil orally (1000 mg) twice daily for three months and gabapentin (300 mg) daily. On the other hand, the control group was treated with gabapentin (300 mg) and placebo. The neuropathy pain severity was measured before and after the end of three-month intervention using Michigan and McGill Pain Questionnaires. Data analysis was performed in SPSS software (version 21) through Fisher's exact test, ANCOVA, multilevel logistic regression, Mann Whitney U test, Kolmogorov-Smirnov test, and the Chi-square tests. P-value less than 0.05 was considered statistically significant.
Results: According to the results obtained from the McGill questionnaire, the mean scores of neuropathy before the intervention were obtained at 10.12±0.57 and 9.85±0.65 in the intervention and control groups, respectively. However, the mean scores of neuropathy after the intervention were estimated at 6.18±0.48 and 8.31±0.60 in the intervention and control groups, respectively, which was statistically significant (P<0.02).
Conclusion: Evening primrose oil is effective in reducing neuropathic pain in type 2 diabetic patients. Therefore, this can be a supplementary treatment for reducing pain associated with diabetic neuropathy.
References
1. Pajouhi M, Shaban Nejad Khas Z, Mohajeri Tehrani MR. Evaluation and prevention of diabetic neuropathy. Tehran Univ Med J. 2007;65(3):1-6. [Persian]
2. Pourmomeny AA, Amini MA, Safaei HA, Hassanzadeh A. The effect of electroanalgsia on pain relief in patient with diabetic neuropathy type II. Iran J Endocrinol Metab. 2009;11(4):363-9. [Persian]
3. Taghizadeh H, Sohrabi Z, Mahaki B. A study on efficacy of pethidine hydrochloride and diclofenac sodium (Diclen) on pain severity after cesarean section. J Ilam Univ Med Sci. 2007;14(4):7-12. [Persian]
4. Fallah LT, Najafi A, Fathizadeh N, Khaledian Z. The effect of evening primrose oil on premenstrual syn. Avicenna J Nurs Midwifery. 2008;16(1):35-45. [Persian]
5. Halat KM, Dennehy CE. Botanicals and dietary supplements in diabetic peripheral neuropathy .J Am Board Fam Med. 2003;16(1):47-57. PMID: 12583650
6. Ghomian B, Jafari H, Khamseh ME. Investigation of some gait characteristics in patients with diabetic neuropathy while wearing rocker sole shoe. Razi J Med Sci. 2016;22(140):55-62. [Persian]
7. Fateh H, Madani SP, Heshmat R, Larijani B. Correlation of Michigan neuropathy screening instrument, United Kingdom screening test and electrodiagnosis for early detection of diabetic peripheral neuropathy. J Diabetes Metab Disord. 2016;15:8. PMID: 27019831 DOI: 10.1186/s40200-016-0229-7
8. Tanhaee Z, Fathi-Ashtiani A, Amini M, Vahedi H, Shaghaghi F. Validation of a revised version of short-form Mc-Gill pain questionnaire (SF-MPQ-2) for IBS patients. Govaresh. 2013;17(2):91-7. [Persian]
9. Ogbera AO, Ezeobi E, Unachukwu C, Oshinaike O. Treatment of diabetes mellitus-associated neuropathy with vitamin E and Eve primrose. Int J Endocrinol Metab. 2014;18(6):846-9. PMID: 25364681 DOI: 10.4103/2230-8210.140270
10. Jamal G, Carmichael H. The effect of γ‐linolenic acid on human diabetic peripheral neuropathy: a double‐blind placebo‐controlled trial. Diabet Med. 1990;7(4):319-23. PMID: 2159860
11. Aboutorab R, Saeedi M. The effect of Antiaging COQ10 plus on the treatment of diabetic neuropathy. Med J Mashhad Univ Med Sci. 2014;57(6):793-8. [Persian]
12. Jantti J, Seppala E, Vapaatalo H, Isomaki H. Evening primrose oil and olive oil in treatment of rheumatoid arthritis. Clin Rheumatol. 1989;8(2):238-44. PMID: 2758770
13. Alvandipour M, Tayebi P, Alizadeh NR, Khodabakhshi H. Comparison between effect of evening primrose oil and vitamin E in treatment of cyclic mastalgia. J Babol Univ Med Sci. 2011;13(1):7-11. [Persian]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s).
Owned by Hamadan University of Medical Sciences
Published by UMSHA Press
Journal Tel: +988138380924
Publisher Tel:+988138380548
Website: http://sjh.umsha.ac.ir
Email: s_ journal[at]umsha.ac.ir
