Volume 18, Issue 4 (Scientific Journal of Hamadan University of Medical Sciences-Winter 2012)                   Avicenna J Clin Med 2012, 18(4): 37-40 | Back to browse issues page

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Arab M, Maktabi M, Zham H, Kimiaei P, Davalo S. Is Ovarian Mass Malignancy Prediction Accuracy Increased by Adding Serum CA125 Measurement to Sonographic Findings?. Avicenna J Clin Med 2012; 18 (4) :37-40
URL: http://sjh.umsha.ac.ir/article-1-211-en.html
1- , drmarab@yahoo.com
Abstract:   (3957 Views)

Introduction & Objective: The aim of the present study is to determine the accuracy of malignancy prediction in adnexal mass if CA125 measurement is added to sonographic findings.

Materials & Methods: In a cross sectional study, AUC of ROC Curve of malignancy prediction based on sonographic findings in comparison to a new model (OMPS2) based on sonography plus serum CA125 was calculated. Pathologic reports of 430 operated adnexal masses were included in the study. Logistic regression analysis was used.

Results: New model (OMPS2) was constructed as follow: OMPS1+1.444 (if CA125=36-200) or 3.842 (if CA125 is above 200).AUC of ROC curve of malignancy prediction increased from 78.1% (based on OMPS1) to 84.3% (in OMPS2).

Conclusion: Serum CA125 measurement in addition to sonography increased the accuracy of malignancy prediction in comparison to only sonography.

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Type of Study: Original | Subject: Other Clinical Specialties

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