Volume 27, Issue 4 (Avicenna Journal of Clinical Medicine-Winter 2021)                   Avicenna J Clin Med 2021, 27(4): 211-216 | Back to browse issues page

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Keramat F, Ghasemi Basir H R, Taher A, Moradi A, Saadatmand A, Owji Nejad P. Evaluation of Antibiotic Resistance to Colistin in Nosocomial Infections with Multidrug-Resistant Acinetobacter. Avicenna J Clin Med 2021; 27 (4) :211-216
URL: http://sjh.umsha.ac.ir/article-1-2143-en.html
1- Professor, Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- Associate Professor, Department of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Assistant Professor, Department of Anesthesiology and Intensive Care, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4- Instructor, Department of Social Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5- MSc in Microbiology, Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
6- General Practitioner, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , pooriaojinezhad2020@gmail.com
Abstract:   (2469 Views)
Background and Objective:Acinetobacter infection is one of the most common nosocomial infections that its antibiotic resistance has increased in recent years.This study aimed to evaluate drug resistance to colistin in nosocomial infections with multidrug-resistant (MDR) Acinetobacterbaumannii.
Materials and Methods:This cross-sectional study was performed on 45 blood or body fluid culture samples collected from hospitalized patients at Sina Hospital, Hamadan, Iran, within 2018-2019.The Minimum Inhibitory Concentration (MIC) was determined using E-test trips and disk diffusion method to evaluate the resistance of Acinetobacterbaumannii to the antibiotic colistin according to the guidelines of the Clinical and Laboratory Standards Institute.The collected data were analyzed in SPSS software (version 16).
Results:In this study, out of 45 patients, 24 (53.3%) and 21 (46.7%) of the subjects were male and female, respectively.The mean age of patients was estimated at 68.0±15.9 years. The antibiotic-resistance of samples was determined using the disk diffusion method. Accordingly, all samples were 100% resistant to ceftriaxone, ceftazidime, ciprofloxacin, cefepime, imipenem, meropenem, ampicillin sulbactam.Out of 45 culture samples examined with MIC, 39 (86.7%) and 6 (13.3%) of samples were sensitive and resistant to colistin, respectively.Based on the results of the disk diffusion method, 21 (46.7%), 19 (42.2%), and 5 (11.1%) of samples were sensitive, intermediate, and resistant to colistin.
Conclusion:Based on the findings, colistin was effective against multidrug-resistant Acinetobacterbaumannii and is suggested to be used in cases of Acinetobacter MDR as an effective treatment in combination with other antibiotics.
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Type of Study: Original | Subject: Infectious Diseases

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