Volume 27, Issue 4 (Avicenna Journal of Clinical Medicine-Winter 2021)                   Avicenna J Clin Med 2021, 27(4): 211-216 | Back to browse issues page


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Keramat F, Ghasemi Basir H R, Taher A, Moradi A, Saadatmand A, Owji Nejad P. Evaluation of Antibiotic Resistance to Colistin in Nosocomial Infections with Multidrug-Resistant Acinetobacter. Avicenna J Clin Med 2021; 27 (4) :211-216
URL: http://sjh.umsha.ac.ir/article-1-2143-en.html
1- Professor, Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- Associate Professor, Department of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Assistant Professor, Department of Anesthesiology and Intensive Care, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4- Instructor, Department of Social Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5- MSc in Microbiology, Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
6- General Practitioner, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , pooriaojinezhad2020@gmail.com
Abstract:   (2469 Views)
Background and Objective:Acinetobacter infection is one of the most common nosocomial infections that its antibiotic resistance has increased in recent years.This study aimed to evaluate drug resistance to colistin in nosocomial infections with multidrug-resistant (MDR) Acinetobacterbaumannii.
Materials and Methods:This cross-sectional study was performed on 45 blood or body fluid culture samples collected from hospitalized patients at Sina Hospital, Hamadan, Iran, within 2018-2019.The Minimum Inhibitory Concentration (MIC) was determined using E-test trips and disk diffusion method to evaluate the resistance of Acinetobacterbaumannii to the antibiotic colistin according to the guidelines of the Clinical and Laboratory Standards Institute.The collected data were analyzed in SPSS software (version 16).
Results:In this study, out of 45 patients, 24 (53.3%) and 21 (46.7%) of the subjects were male and female, respectively.The mean age of patients was estimated at 68.0±15.9 years. The antibiotic-resistance of samples was determined using the disk diffusion method. Accordingly, all samples were 100% resistant to ceftriaxone, ceftazidime, ciprofloxacin, cefepime, imipenem, meropenem, ampicillin sulbactam.Out of 45 culture samples examined with MIC, 39 (86.7%) and 6 (13.3%) of samples were sensitive and resistant to colistin, respectively.Based on the results of the disk diffusion method, 21 (46.7%), 19 (42.2%), and 5 (11.1%) of samples were sensitive, intermediate, and resistant to colistin.
Conclusion:Based on the findings, colistin was effective against multidrug-resistant Acinetobacterbaumannii and is suggested to be used in cases of Acinetobacter MDR as an effective treatment in combination with other antibiotics.
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Type of Study: Original | Subject: Infectious Diseases

References
1. Fauci AS. Infectious diseases: considerations for the 21st century. Clin Infect Dis. 2001;32(5):675-85.PMID: 11229834DOI: 10.1086/319235
2. Peleg AY, Seifert H, Paterson DL. Acinetobacterbaumannii: emergence of a successful pathogen. ClinMicrobiol Rev.2008;21(3):538-82.PMID:18625687DOI:10.1128/CMR.00058-07
3. Howard A, O'Donoghue M, Feeney A, Sleator RD. Acinetobacterbaumannii: an emerging opportunistic pathogen.Virulence. 2012;3(3):243-50. PMID: 22546906DOI: 10.4161/viru.19700
4. Almasaudi SB. Acinetobacter spp. as nosocomial pathogens: epidemiology and resistance features. Saudi J Biol Sci. 2018;25(3):586-96. PMID: 29686523DOI: 10.1016/j.sjbs.2016.02.009
5. Manikal VM, Landman D, Saurina G, Oydna E, Lal H, Quale J. Endemic carbapenem-resistant Acinetobacter species in Brooklyn, New York: citywide prevalence, interinstitutional spread, and relation to antibiotic usage. Clin Infect Dis. 2000;31(1):101-6.PMID: 10913404DOI: 10.1086/313902
6. Arroyo LA, Garcia-Curiel A, Pachon-Ibanez ME, Llanos AC, Ruiz M, Pachon J, et al. Reliability of the E-test method for detection of colistin resistance in clinical isolates of Acinetobacterbaumannii. J ClinMicrobiol. 2005;43(2):903-5. PMID: 15695701DOI: 10.1128/JCM.43.2.903-905.2005
7. De Luca M, Angelino G, Calò Carducci FI, Martino A, Bernardi S, Bernaschi P, et al. Multidrug-resistant Acinetobacterbaumannii infection in children. BMJ Case Rep. 2011;2011:bcr0220113807. PMID: 22688471DOI: 10.1136/bcr.02.2011.3807
8. Wong D, Nielsen TB, Bonomo RA, Pantapalangkoor P, Luna B, Spellberg B. Clinical and pathophysiological overview of Acinetobacter infections: a century of challenges. ClinMicrobiol Rev. 2017;30(1):409-47. PMID: 27974412DOI: 10.1128/CMR.00058-16
9. Shojaei L, Mohammadi M, Beigmohammadi MT, Doomanlou M, Abdollahi A, Feizabadi MM, et al. Clinical response and outcome of pneumonia due to multi-drug resistant Acinetobacterbaumannii in critically ill patients. Iran J Microbiol. 2016;8(5):288-97. PMID: 28149487
10. Chien ST, Lin CH, Hsueh JC, Li PL, Hsu CH, Chang SH, et al. Mutation of gyrA and parC in clinical isolates of Acinetobacterbaumannii and its relationship with antimicrobial drugs resistance in Taiwan. Ann Microbiol. 2009;59(2):369-72.DOI: 10.1007/BF03178341
11. Antunes LC, Visca P, Towner KJ. Acinetobacterbaumannii: evolution of a global pathogen. Pathog Dis. 2014;71(3):292-301.PMID: 24376225DOI: 10.1111/2049-632X.12125
12. Howard A, O'Donoghue M, Feeney A, Sleator RD. Acinetobacterbaumannii: an emerging opportunistic pathogen. Virulence. 2012;3(3):243-50. PMID: 22546906DOI: 10.4161/viru.19700
13. Moradi J, Hashemi FB, Bahador A. Antibiotic resistance of Acinetobacterbaumannii in Iran: a systemic review of the published literature. Osong Public Health Res Perspect. 2015;6(2):79-86. PMID: 25938016DOI: 10.1016/j.phrp.2014.12.006
14. Bialvaei AZ, Kouhsari E, Salehi-Abargouei A, AmirmozafariN, Ramazanzadeh R, Ghadimi-Daresajini A, et al. Epidemiology of multidrug-resistant Acinetobacterbaumannii strains in Iran: a systematic review and meta-analysis. J Chemother. 2017;29(6):327-37. PMID: 28622734DOI: 10.1080/1120009X.2017.1338377
15. Ghasemian R, Ahanjan M, Fatehi E, Shokri M. Prevalence and antibiotic resistance pattern of acinetobacter isolated from patients admitted in ICUs in Mazandaran, Northern Iran. Global J Health Sci. 2016;8(11):112-9.DOI:10.5539/gjhs.v8n11p112
16. Safdari H, Maghrouni A, Farsiani H. Study of Imipenem and Colistin resistance rates of isolated Acinetobacterbaumannii from hospitalized patients in Imam Reza and Ghaem hospitals of Mashhad through E-test. Iran J ObstetGynecolInfertil. 2019;21(11):32-6. [Persian]
17. Moghadasi M, Kalantar-Neyestanaki D, Karami-Zarandi M, Rahdar HA, Jasemi S, Feizabadi MM. Investigation of antimicrobial susceptibility patterns and frequency of bla OXA genes in carbapenem resistant Acinetobacterbaumanniistrains. Sci J Kurdistan Univ Med Sci.2018;23(5):108-19. [Persian]
18. Angoti G, Godarzi H, Besharat M, Hajizadeh M, ZarringhalamMoghaddam M. Evaluation of antibiotic resistance of clinical Acinetobacterbaumannii isolated of Tabriz hospital by disk diffusion and MIC methods. Res Med. 2014;38(2):106-10. [Persian]
19. Majzoobi MM, Pirdehghan A, Rashidian Z, Saadatmand A. Etiologic agents and antibiotic resistance pattern of community- and hospital-acquired infections. Avicenna J Clin Med. 2018;25(1):41-8. DOI: 10.21859/ajcm.25.1.41
20. Soudeiha MAH, Dahdouh EA, Azar E, Sarkis DK, Daoud Z. In vitro evaluation of the colistin-carbapenem combination in clinical isolates of A. baumannii using the checkerboard, Etest, and time-kill curve techniques.Front Cell Infect Microbiol. 2017;7:209. PMID: 28596943DOI: 10.3389/fcimb.2017.00209
21. Sohail M, Rashid A, Aslam B, Waseem M, Shahid M, Akram M, et al. Antimicrobial susceptibility of Acinetobacter clinical isolates and emerging antibiogram trends for nosocomial infection management. Rev Soc Bras Med Trop. 2016;49(3):300-4. PMID: 27384826DOI: 10.1590/0037-8682-0111-2016
22. Szejbach A, Mikucka A, Bogiel T, Gospodarek E. Usefulness of phenotypic and genotypic methods for metallo-beta-lactamases detection in carbapenem-resistant Acinetobacterbaumannii strains. Med SciMonit Basic Res. 2013;19:32-6. PMID: 23333953DOI: 10.12659/msmbr.883744
23. Safari M, Saidijam M, Bahador A, Jafari R, Alikhani MY. High prevalence of multidrug resistance and metallo-beta-lactamase (MbetaL) producing Acinetobacter baumannii isolated from patients in ICU wards, Hamadan, Iran. J Res Health Sci. 2013;13(2):162-7. PMID: 24077474

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