Volume 30, Issue 3 (Avicenna Journal of Clinical Medicine-Autumn 2023)
Avicenna J Clin Med 2023, 30(3): 129-136 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Sheikh V, Kargar F, Moradi A, Khaki Zadeh S, Nadi E. Urine Albumin/Creatinine Ratio and Serum Uric Acid as Predictors of Severity in Patients with Chronic Obstructive Pulmonary Disease. Avicenna J Clin Med 2023; 30 (3) :129-136
URL: http://sjh.umsha.ac.ir/article-1-2805-en.html
URL: http://sjh.umsha.ac.ir/article-1-2805-en.html
1- Clinical Research Development Unit of Shahid Beheshti Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran
4- Clinical Research Development Unit of Shahid Beheshti Hospital, Hamadan University of Medical Sciences, Hamadan, Iran , nadi@umsha.ac.ir
2- Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran
4- Clinical Research Development Unit of Shahid Beheshti Hospital, Hamadan University of Medical Sciences, Hamadan, Iran , nadi@umsha.ac.ir
Abstract: (526 Views)
Background and Objective: As a global healthcare issue, Chronic Obstructive Pulmonary Disease (COPD) is mainly associated with smoking. Nonetheless, environmental and occupational issues are also linked to its development. The present study aimed to assess the urine albumin-to-creatinine ratio (ACR) and serum uric acid (SUA) levels as predictors of disease severity in COPD patients.
Materials and Methods: This cross-sectional study was conducted on 67 patients diagnosed with COPD using the Global Initiative for Obstructive Lung Disease diagnostic criteria. The participants were patients who were either referred to the subspecialty clinic of the pulmonology and spirometry unit of Hamadan Shahid Beheshti Hospital or were hospitalized in the pulmonology ward. Blood and urine samples were taken from the COPD patients, and the serum uric acid, urine albumin, and urine creatinine levels were assessed and recorded in a checklist. The data were analyzed in SPSS software (version 23) at a significance level of 0.05.
Results: In terms of gender, 5.7% of the participants were male and 34.3% were female. The mean age of patients was 61.77 years. The stages of disease severity in the patients were as follows: 20.89%, 22.38%, 5.73%, and 2.98% of cases had very severe, severe, moderate, and mild COPD, respectively. The regression analysis results demonstrated that SUA levels could significantly predict the FEV1 in COPD patients; nonetheless, urine ACR could not predict the FEV1 scores.
Conclusion: As evidenced by the result of the present study, the FEV1 in COPD patients and disease severity could be predicted by the SUA levels. Therefore, it is recommended to consider monitoring and assessing non-pulmonary factors, especially SUA levels, in the treatment of COPD patients.
Materials and Methods: This cross-sectional study was conducted on 67 patients diagnosed with COPD using the Global Initiative for Obstructive Lung Disease diagnostic criteria. The participants were patients who were either referred to the subspecialty clinic of the pulmonology and spirometry unit of Hamadan Shahid Beheshti Hospital or were hospitalized in the pulmonology ward. Blood and urine samples were taken from the COPD patients, and the serum uric acid, urine albumin, and urine creatinine levels were assessed and recorded in a checklist. The data were analyzed in SPSS software (version 23) at a significance level of 0.05.
Results: In terms of gender, 5.7% of the participants were male and 34.3% were female. The mean age of patients was 61.77 years. The stages of disease severity in the patients were as follows: 20.89%, 22.38%, 5.73%, and 2.98% of cases had very severe, severe, moderate, and mild COPD, respectively. The regression analysis results demonstrated that SUA levels could significantly predict the FEV1 in COPD patients; nonetheless, urine ACR could not predict the FEV1 scores.
Conclusion: As evidenced by the result of the present study, the FEV1 in COPD patients and disease severity could be predicted by the SUA levels. Therefore, it is recommended to consider monitoring and assessing non-pulmonary factors, especially SUA levels, in the treatment of COPD patients.
Type of Study: Original |
Subject:
Lung Diseases
Extended Abstract [HTML 28 KB] (36 Download)
References
1. Breda C, Ross M, Ross S. Chronic Obstructive Pulmonary Disease. International Encyclopedia of Public Health . 2017: 28–35. DOI: 10.1016/B978-0-12-803678-5.00073-4.
2. Chiappori A, Folli C, Balbi F, Caci E, Riccio AM, De Ferrari L, Melioli G, Braido F, Canonica GW. CD4(+)CD25(high)CD127(-) regulatory T-cells in COPD: smoke and drugs effect. World Allergy Organ J. 2016;9:5. DOI: 10.1186/s40413-016-0095-2.
3. Gudarzi MT, Abdi M, Tavilani H, Nadi E, Rashidi M. Adenosine deaminase activity in COPD patients and healthy subjects. Iranian J Allergy Asthma Immunol. 2010; 9(1):7-12.
4. Huang YJ, Erb-Downward JR, Dickson RP, Curtis JL, Huffnagle GB, Han MK. Understanding the role of the microbiome in chronic obstructive pulmonary disease: principles, challenges, and future directions. Trans Res. 2017;179:71-83. PMID: 27392936 DOI: 10.1016/j.trsl.2016.06.007
5. World Health Organization [WHO]. COPD Burden. 2014. http://www.who.int/respiratory/copd/burden/en/index.html
6. Goodridge DM. COPD as a Life-Limiting Illness: Implications for Advanced Practice Nurses. Adv Pract Nurs eJ. 2006;6(4).
7. Wang LQ, Wang CL, Xu LN, Hua DF. The expression research of miR‐210 in the elderly patients with COPD combined with ischemic stroke. Eur Rev Med Pharmacol Sci. 2016;20(22):4756-60. PMID: 27906445
8. Naghavi M. Condition of death in 18 provinces in the year 2001. Tehran: Tandis. 2003:90-93.
9. Mc Garvey L, Morice A. Clinical cough and its mechanisms. Respir Physio Neurobiol. 2006;152(3):363–71. PMID: 16406741 DOI: 10.1016/j.resp.2005.11.011
10. Smith J, Woodcock A. Cough and its importance in COPD. Int J Chron Obstruct Pulmon Dis. 2006;1(3): 305–14. PMID: 18046867 DOI: 10.2147/copd.2006.1.3.305
11. Kasper D, Fauci A, Hauser S, Longo D, Jameson L, Loscalzo J, et al. Harrison's privciples of internal medicine. New York: Mc Graw Hill Education; 2015.
12. Shojaei F. Quality of life of patients with heart failure. Hayat. 2008;14(2):5-13.
13. Lane N, Robins RA, Corne J, Fairclough L. Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells. Clin Sci. 2010;119(2):75–86. PMID: 20402669 DOI: 10.1042/CS20100033
14. Masroor DD, Rafii F, Fadaeeaghdam N, Hoseini AF. Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease. Iran J Nurs. 2012;25(76):19-27.
15. Kocak ND, Sasak G, Akturk UA, Akgun M, Boga S, Sengul A, Gungor S, Arinc S. Serum uric acid levels and uric acid/creatinine ratios in stable chronic obstructive pulmonary disease (COPD) patients: Are these parameters efficient predictors of patients at risk for exacerbation and/or severity of disease. Med Sci Monit. 2016;22:4169. PMID: 27811831 DOI: 10.12659/msm.897759
16. Bozkus F, Dikmen N, Samur A. Microalbuminuria in subjects with COPD: relationship to the new version of global initiative for chronic obstructive lung disease staging. Respir Care. 2017;62(3):307-14. PMID: 27965420 DOI: 10.4187/respcare.05168
17. Agrawal A, Garg R, Sahu D, Kumar M. Study the association of chronic obstructive pulmonary disease with early endothelial dysfunction and its impact on cardiovascular system by estimating urinary albumin creatinine ratio. Lung India. 2017;34(2):138 PMID: 28360461 DOI: 10.4103/0970-2113.201299
18. Zeraati AA, Rezaeetalab F, Nosrat Y, Sharifipour F, MohammadzadehLari S, BeladiMousavi SS. Correlation of Urinary Albumin Creatinine Ratio with Gasometric Parameters in Patients with Chronic Obstructive Pulmonary Disease (COPD). Mashhad Univ Med J .2013;56(2):99-103. DOI: 10.22038/MJMS.2013.849
19. Nadi E, Assari MJ, Zamanian A. The Relationship between Some Spirometric Disorders and Methyl Methacrylate Concentrations in Hamadan Dental Prosthodontics Laboratories. Hamadan Univ Med Sci J. 2010;17(1):31-38.
20. Brusasco V, Crapo R , Viegi G. Series ATS/ERS task force: standardization of lung function testing. Eur Respir J. 2005;26:153-161. DOI: 10.1183/09031936.05.00035205
21. Nadi E, Hajilouei M, Abdoli S, Basiri Z. Frequency of alpha-1 antitrypsin deficiency in chronic obstructive pulmonary disease patients admitted to Hamadan Ekbatan Hospital. Qom Univ Med Sci J. 2011;5(1):7-11.
22. Halvani A, Tavakoli M, SafariKamalabadi M. Epidemiology of Chronic Obstructive Pulmonary Disease in Patients Admitted. Shahid Sadoughi Univ Med Sci J. 2009;17(2):3-9.
23. Usha S, Karthik S, Thiriveni B G, Jegatheesh R, A Study of Serum Uric Acid Levels in Chronic Obstructive Pulmonary Disease. IOSR JDMS. 2017;16(12):49-55. DOI: 10.9790/0853-1612104955
24. Kahnert K, Alter P, Welte T, Huber RM, Behr J, Biertz F, Watz H, Bals R, Vogelmeier CF, Jorres RA. Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach. Respir Res J. 2018;19(1):110. PMID: 29866121 DOI: 10.1186/s12931-018-0815-y
25. Vafaei A, Saremi Z, MortazaviMoghaddam SG, JavidArabshahi Z. The Relationship between Serum Uric Acid and Severity of Chronic Obstructive Pulmonary Disease (COPD). J Cardiothorac Med. 2017;5(3):181-6.
26. Romundstad S, Naustdal T, Romundstad PR, Sorger H, Langhammer A. COPD and microalbuminuria: a 12-year follow-up study. Eur Respir J. 2014;43:1042-50. PMID: 24435009 DOI: 10.1183/09031936.00160213
27. Mehmood K, Sofi FA. Microalbuminuria and Hypoxemia in Patients with COPD. Pulm Respir Med. 2015;5(3):280. DOI: 10.4172/2161-105X.1000280
28. Agrawal A, Garg R, Sahu D, Kumar M. Study the association of chronic obstructive pulmonary disease with early endothelial dysfunction and its impact on cardiovascular system by estimating urinary albumin creatinine ratio. Lung India J. 2017;34(2):138-43. PMID: 28360461 DOI: 10.4103/0970-2113.201299
29. Sahay S, Prasad MK. Microalbuminuria and COPD: A Clinical and Physiological Association. Int J Med Res Prof. 2018;4(4):270-2. DOI: 10.21276/ijmrp.2018.4.4.062
30. Bulcun E, Ekici M, Ekici A, Kisa U. Microalbuminuria in chronic obstructive pulmonary disease. COPD. J Chron Obst Pulmon Dis. 2013;10(2):186-92. PMID: 23547630 DOI: 10.3109/15412555.2012.735292.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s).
Owned by Hamadan University of Medical Sciences
Published by UMSHA Press
Journal Tel: +988138380924
Publisher Tel:+988138380548
Website: http://sjh.umsha.ac.ir
Email: s_ journal[at]umsha.ac.ir
