Introduction & Objective: This study compared the personality profile of cancer patients with that of normal persons. The aim was identifying personality traits related to people who suffered from cancer, and helping them to cope with the situation and adjust with life. Materials & Methods: This research was a casual comparative study. For this purpose 100 persons were selected from hematology and oncology center and asked to complete (NEO) personality inventory. Then 94 persons were selected as matched group.

Results: The result showed that neuroticism was high in cancer patients (p<0.00). Also there were significant differences between normal people and cancer patients in adaptibility and extroversion with high scores in normal people (p<0.05). But there were no significant difference between the two groups in agreeableness and conscientious.

Conclusion: In general the result of this research demonstrated that the cancer patients were more neurotic and less adaptable and extrovert therefore they need psychotherapy.