Volume 31, Issue 2 (Avicenna Journal of Clinical Medicine-Summer 2024)
Avicenna J Clin Med 2024, 31(2): 70-75 |
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Abbasi S R, Shariatpanahi E, Nabavi S R, Moradkhani S, Moradi A, Emami S F. Investigating the Effect of Coenzyme Q10 in the Treatment of Sudden Sensorineural Hearing Loss. Avicenna J Clin Med 2024; 31 (2) :70-75
URL: http://sjh.umsha.ac.ir/article-1-3005-en.html
URL: http://sjh.umsha.ac.ir/article-1-3005-en.html
Seyed Rohollah Abbasi1 
, Elnaz Shariatpanahi2 , Seyed Rouhollah Nabavi1 , Shirin Moradkhani3 , Abbas Moradi4 , Seyede Faranak Emami 5
, Elnaz Shariatpanahi2 , Seyed Rouhollah Nabavi1 , Shirin Moradkhani3 , Abbas Moradi4 , Seyede Faranak Emami 5
1- Department of Otorhinolaryngology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Otorhinolaryngology, School of Medicine, Hearing Disorder Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences Hamadan, Iran
4- School of Medicine, Hamadan University of Medical Sciences Hamadan, Iran
5- Department of Audiology, School of Rehabilitation Sciences, Hearing Disorder Research Center, Hamadan University of Medical Sciences, Hamadan, Iran ,faranak_imami@yahoo.com
2- Department of Otorhinolaryngology, School of Medicine, Hearing Disorder Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences Hamadan, Iran
4- School of Medicine, Hamadan University of Medical Sciences Hamadan, Iran
5- Department of Audiology, School of Rehabilitation Sciences, Hearing Disorder Research Center, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract: (847 Views)
Background and Objective: Sudden sensorineural hearing loss (SSNHL) is a complication that is usually unilateral and can be accompanied by tinnitus and vertigo. Although various infectious, vascular, and immune etiologies have been proposed for SSNHL, the cause is unknown in most cases. Therefore, this study aimed to determine the effect of coenzyme Q10 in the treatment of SSNHL.
Materials and Methods: This study was a double-blind, randomized, controlled clinical trial, which was conducted using the available sampling method. A total of 60 patients with SSNHL (18-70 years old) lasting less than one month were divided into two groups: intervention and control. The routine treatment of both groups included weekly injections of dexamethasone in the middle ear for 3 weeks. The intervention group also received 100 mg of coenzyme Q10 per day for 4 weeks, while the control group received a placebo. Patients were evaluated by basic audiological tests at the baseline and third and sixth months after the treatment. Statistical analysis of findings was done in SPSS26 software.
Results: The difference in the mean pure tone hearing thresholds of the intervention and control groups was significant in the third month (29.33±15.96 dB and 35.34±12.24 dB; P=0.02) and sixth month (dB 28.00±16.27 and dB 34.33±11.87; P=0.01).
Conclusion: In patients with SSNHL, combined treatment with oral coenzyme Q10 at the rate of 100 mg per day, along with intratympanic injection of dexamethasone for four weeks, can improve pure tone hearing thresholds and facilitate the treatment
Materials and Methods: This study was a double-blind, randomized, controlled clinical trial, which was conducted using the available sampling method. A total of 60 patients with SSNHL (18-70 years old) lasting less than one month were divided into two groups: intervention and control. The routine treatment of both groups included weekly injections of dexamethasone in the middle ear for 3 weeks. The intervention group also received 100 mg of coenzyme Q10 per day for 4 weeks, while the control group received a placebo. Patients were evaluated by basic audiological tests at the baseline and third and sixth months after the treatment. Statistical analysis of findings was done in SPSS26 software.
Results: The difference in the mean pure tone hearing thresholds of the intervention and control groups was significant in the third month (29.33±15.96 dB and 35.34±12.24 dB; P=0.02) and sixth month (dB 28.00±16.27 and dB 34.33±11.87; P=0.01).
Conclusion: In patients with SSNHL, combined treatment with oral coenzyme Q10 at the rate of 100 mg per day, along with intratympanic injection of dexamethasone for four weeks, can improve pure tone hearing thresholds and facilitate the treatment
Type of Study: Original |
Subject:
Otorhinolaryngology
Extended Abstract [HTML 38 KB] (49 Download)
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