Volume 32, Issue 3 (Avicenna Journal of Clinical Medicine-Autumn 2025)
Avicenna J Clin Med 2025, 32(3): 172-179 |
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Haddad M, Sheybani F, Birjandi S. Evaluation of Epidemiological, Clinical, and Paraclinical Features, as well as Clinical Outcomes of Hospitalized Patients with Pyogenic Liver Abscess. Avicenna J Clin Med 2025; 32 (3) :172-179
URL: http://sjh.umsha.ac.ir/article-1-3225-en.html
URL: http://sjh.umsha.ac.ir/article-1-3225-en.html
1- Department of Infectious Diseases and Tropical Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , Haddadnm@mums.ac.ir
2- Department of Infectious Diseases and Tropical Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Infectious Diseases and Tropical Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract: (41 Views)
Background and Objective: Liver abscess is a potentially life-threatening disease and one of the leading causes of hospitalization in low- and middle-income countries. The present study aimed to determine the epidemiological, clinical, and paraclinical characteristics, as well as the clinical outcomes of hospitalized patients with liver abscess.
Materials and Methods: The present study was conducted on hospitalized adults with pyogenic liver abscesses from 2011 to 2022 at Imam Reza Hospital in Mashhad, Iran. Demographic information, clinical manifestations, paraclinical data, pyogenic liver abscess and clinical outcomes (death or survival) of the patients were examined, and data analysis was performed using the SPSS software. Logistic regression test was employed to assess factors associated with mortality. A significance level of P-value less than 0.05 was considered for all analyses.
Results: A total of 145 patients were examined. The median age of the participants was 63 years (range: 45-75 years). 49% of patients were elderly, 55.9% were male, and 51% had hepatobiliary problems. The most common underlying disease was cardiovascular disease (34.5%).52.9% of patients had only one abscess. E. coli (33.8%), Klebsiella (20%), and Enterococcus (18.4%) were the most common organisms causing abscesses. Thrombocytopenia, leukocytosis, bacteremia, and elevated ALT were associated with an increased risk of death by factors of 4.87, 3.68, 3.5, and 3.47, respectively.
Conclusion: Half of liver abscess cases occur in the elderly and patients with underlying hepatobiliary diseases. Thrombocytopenia, leukocytosis, elevated ALT, and bacteremia have been identified as predictors of mortality. Therefore, it is recommended to pay closer attention to timely treatment in patients with these laboratory abnormalities.
Materials and Methods: The present study was conducted on hospitalized adults with pyogenic liver abscesses from 2011 to 2022 at Imam Reza Hospital in Mashhad, Iran. Demographic information, clinical manifestations, paraclinical data, pyogenic liver abscess and clinical outcomes (death or survival) of the patients were examined, and data analysis was performed using the SPSS software. Logistic regression test was employed to assess factors associated with mortality. A significance level of P-value less than 0.05 was considered for all analyses.
Results: A total of 145 patients were examined. The median age of the participants was 63 years (range: 45-75 years). 49% of patients were elderly, 55.9% were male, and 51% had hepatobiliary problems. The most common underlying disease was cardiovascular disease (34.5%).52.9% of patients had only one abscess. E. coli (33.8%), Klebsiella (20%), and Enterococcus (18.4%) were the most common organisms causing abscesses. Thrombocytopenia, leukocytosis, bacteremia, and elevated ALT were associated with an increased risk of death by factors of 4.87, 3.68, 3.5, and 3.47, respectively.
Conclusion: Half of liver abscess cases occur in the elderly and patients with underlying hepatobiliary diseases. Thrombocytopenia, leukocytosis, elevated ALT, and bacteremia have been identified as predictors of mortality. Therefore, it is recommended to pay closer attention to timely treatment in patients with these laboratory abnormalities.
Type of Study: Original |
Subject:
Infectious Diseases
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