Volume 32, Issue 3 (Avicenna Journal of Clinical Medicine-Autumn 2025)
Avicenna J Clin Med 2025, 32(3): 140-146 |
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Alizamir A, Rashidi S, Ahmadi M, Khanlarzadeh E. Investigation of Serum Antibody Levels against Chlamydia Trachomatis in Women with Ectopic Pregnancy. Avicenna J Clin Med 2025; 32 (3) :140-146
URL: http://sjh.umsha.ac.ir/article-1-3233-en.html
URL: http://sjh.umsha.ac.ir/article-1-3233-en.html
Investigation of Serum Antibody Levels against Chlamydia Trachomatis in Women with Ectopic Pregnancy
1- Department of Pathology, School of Medicine, Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran & Clinical Research Development Unit of Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2- Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Obstetrics and Gynecology, School of Medicine, Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran & Clinical Research Development Unit of Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran ,ahmadi_1011@yahoo.com
4- Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Obstetrics and Gynecology, School of Medicine, Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran & Clinical Research Development Unit of Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran ,
4- Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract: (6 Views)
Background and Objective: Ectopic pregnancy is a life-threatening complication in pregnant women, and the role of Chlamydia trachomatis infection as one of its risk factors has been noted. The present study aimed to investigate the serum antibody levels against Chlamydia trachomatis in women with ectopic pregnancy and compare them with those in women with intrauterine pregnancy.
Materials and Methods: The present case-control study was conducted at Fatemieh Hospital, Hamadan, Iran, during 2023-2024. A total of 70 women, including 35 with ectopic pregnancy and 35 with intrauterine pregnancy, were selected by convenience sampling. Serum IgG antibody levels against Chlamydia trachomatis were measured by enzyme-linked immunosorbent assay (ELISA). Data were analyzed using t-test, Mann-Whitney, and Chi-square statistical tests.
Results: The mean antibody level in the ectopic pregnancy group (8.16 ± 3.16) was significantly higher than that in the intrauterine pregnancy group (4.21 ± 1.40) (P<0.001). In the intrauterine pregnancy group, the mean serum antibody level against Chlamydia trachomatis was significantly higher in women with a history of cesarean section (4.97 ± 1.03) or pelvic surgery (5.15 ± 1.77) (P=0.04). In contrast, other obstetric factors, including miscarriage, infertility treatment, history of ectopic pregnancy, pelvic infection, medication use, and underlying diseases, had no significant effect on antibody levels (P>0.05). Additionally, in the ectopic pregnancy group, none of the above factors caused a considerable difference in antibody levels (P>0.05).
Conclusion: A significant increase in serum antibody levels against Chlamydia trachomatis in women with ectopic pregnancy suggests a potential role of this infection in the occurrence of this complication. Timely screening and treatment of Chlamydia trachomatis may be effective in the prevention of ectopic pregnancy and reduction of its complications.
Materials and Methods: The present case-control study was conducted at Fatemieh Hospital, Hamadan, Iran, during 2023-2024. A total of 70 women, including 35 with ectopic pregnancy and 35 with intrauterine pregnancy, were selected by convenience sampling. Serum IgG antibody levels against Chlamydia trachomatis were measured by enzyme-linked immunosorbent assay (ELISA). Data were analyzed using t-test, Mann-Whitney, and Chi-square statistical tests.
Results: The mean antibody level in the ectopic pregnancy group (8.16 ± 3.16) was significantly higher than that in the intrauterine pregnancy group (4.21 ± 1.40) (P<0.001). In the intrauterine pregnancy group, the mean serum antibody level against Chlamydia trachomatis was significantly higher in women with a history of cesarean section (4.97 ± 1.03) or pelvic surgery (5.15 ± 1.77) (P=0.04). In contrast, other obstetric factors, including miscarriage, infertility treatment, history of ectopic pregnancy, pelvic infection, medication use, and underlying diseases, had no significant effect on antibody levels (P>0.05). Additionally, in the ectopic pregnancy group, none of the above factors caused a considerable difference in antibody levels (P>0.05).
Conclusion: A significant increase in serum antibody levels against Chlamydia trachomatis in women with ectopic pregnancy suggests a potential role of this infection in the occurrence of this complication. Timely screening and treatment of Chlamydia trachomatis may be effective in the prevention of ectopic pregnancy and reduction of its complications.
Type of Study: Original |
Subject:
Obstetrics & Gynecology
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