Volume 32, Issue 2 (Avicenna Journal of Clinical Medicine-Summer 2025)
Avicenna J Clin Med 2025, 32(2): 127-132 |
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Torkaman Asadi F, Sheikh V, Shakarami A H. A Late-Onset Cytomegalovirus Gastritis in A Kidney Transplant Recipient: A Case Report. Avicenna J Clin Med 2025; 32 (2) :127-132
URL: http://sjh.umsha.ac.ir/article-1-3249-en.html
URL: http://sjh.umsha.ac.ir/article-1-3249-en.html
1- Infectious Disease Research Center, Avicenna Institute of Clinical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran & Department of Infectious Diseases, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- 3 School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran ,amirhosseinshakarami4@gmail.com
2- Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- 3 School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract: (53 Views)
Background: Cytomegalovirus (CMV) is a major opportunistic pathogen in immunocompromised patients, especially among kidney transplant recipients. This virus can cause widespread infections, especially in the gastrointestinal tract, due to the weakening of the immune system.
Case Report: A 62-year-old female patient with a kidney transplant performed 16 years prior presented with weight loss, persistent dyspepsia, epigastric pain, nausea, vomiting, and low-grade fever. Endoscopy of the stomach revealed multiple gastric erosions in the antral region. Biopsy showed no evidence of malignancy or infection with Helicobacter pylori; however, intranuclear inclusions and an "owl-eye" appearance were observed. Tissue PCR was also positive for CMV, revealing a CMV serum viral load of 6,206 copies/ml. Treatment was initiated with intravenous ganciclovir and subsequently switched to oral valganciclovir, resulting in clinical improvement and a reduction in viral load.
Conclusion: This case report underscores the importance of the potential for late-onset CMV infection in transplant recipients and the necessity for long-term monitoring and regular screening in this group.
Case Report: A 62-year-old female patient with a kidney transplant performed 16 years prior presented with weight loss, persistent dyspepsia, epigastric pain, nausea, vomiting, and low-grade fever. Endoscopy of the stomach revealed multiple gastric erosions in the antral region. Biopsy showed no evidence of malignancy or infection with Helicobacter pylori; however, intranuclear inclusions and an "owl-eye" appearance were observed. Tissue PCR was also positive for CMV, revealing a CMV serum viral load of 6,206 copies/ml. Treatment was initiated with intravenous ganciclovir and subsequently switched to oral valganciclovir, resulting in clinical improvement and a reduction in viral load.
Conclusion: This case report underscores the importance of the potential for late-onset CMV infection in transplant recipients and the necessity for long-term monitoring and regular screening in this group.
Type of Study: Case Report |
Subject:
Liver & Digestive Diseases
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