Volume 33, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2026)
Avicenna J Clin Med 2026, 33(1): 13-20 |
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Jamshidi M, Derakhshandeh K, Alirezaei P, Doosti Irani A, Moafi B. Comparison of Topical 4% Hydroquinone and Topical 2% Glucosamine in the Treatment of Melasma. Avicenna J Clin Med 2026; 33 (1) :13-20
URL: http://sjh.umsha.ac.ir/article-1-3293-en.html
URL: http://sjh.umsha.ac.ir/article-1-3293-en.html
Mohammad Jamshidi1 
, Katayoun Derakhshandeh2 , Pedram Alirezaei3 , Amin Doosti Irani4 , Behmam Moafi3
, Katayoun Derakhshandeh2 , Pedram Alirezaei3 , Amin Doosti Irani4 , Behmam Moafi3
1- Department of Dermatology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , jamshidim84@yahoo.com
2- Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3- Dermatologist, Tehran, Iran
4- Department of Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3- Dermatologist, Tehran, Iran
4- Department of Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract: (20 Views)
Background and Objective: Melasma is a benign pigmentary skin disease, especially in the face area, which changes the appearance of the patient. For the treatment of this disease, various treatment modalities have been used so far; however, none provides a definitive cure. This study aimed to investigate and compare the effectiveness of topical hydroquinone 4%, the standard treatment, with that of 2% glucosamine in the treatment of melasma.
Materials and Methods: This double-blind randomized clinical trial was performed on 24 patients with mild melasma who were selected using convenience and consecutive sampling methods. One side of the face was randomly assigned to be treated with 4% topical hydroquinone, and the opposite side with 2% topical glucosamine. Both sides of the face were examined at baseline and 8 weeks after treatment, and compared in terms of lesion severity with the modified MASI Score. The data were analyzed in SPSS software (version 26) at a confidence level of 95%.
Results: Mean age of the patients was 36.00±9.83 years. Among the 24 patients, 18 (75.0%) were women, and 6 (25.0%) were men. In the 4% topical hydroquinone and 2% topical glucosamine treatment groups, the mean modified MASI scores before treatment were 4.51±1.70 and 4.50±1.72, respectively, while the corresponding post-treatment scores were 1.98±1.11 and 3.15±1.42, respectively. Moreover, the mean differences between the modified MASI score before and after the treatment in the 4% topical hydroquinone and 2% topical glucosamine treatment groups were 2.54±1.68 and 1.34±1.04, respectively.
Conclusion: Both topical hydroquinone 4% and glucosamine topical 2% were effective in the treatment of mild facial melasma. However, 4% topical hydroquinone demonstrated greater efficacy than 2% topical glucosamine.
Materials and Methods: This double-blind randomized clinical trial was performed on 24 patients with mild melasma who were selected using convenience and consecutive sampling methods. One side of the face was randomly assigned to be treated with 4% topical hydroquinone, and the opposite side with 2% topical glucosamine. Both sides of the face were examined at baseline and 8 weeks after treatment, and compared in terms of lesion severity with the modified MASI Score. The data were analyzed in SPSS software (version 26) at a confidence level of 95%.
Results: Mean age of the patients was 36.00±9.83 years. Among the 24 patients, 18 (75.0%) were women, and 6 (25.0%) were men. In the 4% topical hydroquinone and 2% topical glucosamine treatment groups, the mean modified MASI scores before treatment were 4.51±1.70 and 4.50±1.72, respectively, while the corresponding post-treatment scores were 1.98±1.11 and 3.15±1.42, respectively. Moreover, the mean differences between the modified MASI score before and after the treatment in the 4% topical hydroquinone and 2% topical glucosamine treatment groups were 2.54±1.68 and 1.34±1.04, respectively.
Conclusion: Both topical hydroquinone 4% and glucosamine topical 2% were effective in the treatment of mild facial melasma. However, 4% topical hydroquinone demonstrated greater efficacy than 2% topical glucosamine.
Type of Study: Original |
Subject:
Dermatology
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