Volume 33, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2026)
Avicenna J Clin Med 2026, 33(1): 39-45 |
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Mafakheri N, Eqbalian F, Naderifar H, Najafi Vosough R, Kazem Sabzei M, Mehri F. Oxidative Stress and Antioxidant Defense in Infants with Respiratory Distress Syndrome. Avicenna J Clin Med 2026; 33 (1) :39-45
URL: http://sjh.umsha.ac.ir/article-1-3316-en.html
URL: http://sjh.umsha.ac.ir/article-1-3316-en.html
Nesa Mafakheri1 
, Fatemeh Eqbalian2 , Homa Naderifar1 , Roya Najafi Vosough3 , Mohammad Kazem Sabzei4 , Fereshteh Mehri5
, Fatemeh Eqbalian2 , Homa Naderifar1 , Roya Najafi Vosough3 , Mohammad Kazem Sabzei4 , Fereshteh Mehri5
1- Hearing Disorders Research Center, Avicenna Institute of Clinical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
2- Hearing Disorders Research Center, Avicenna Institute of Clinical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran & Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Research Center for Health Sciences, Institute of Health Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5- Nutrition Health Research Center, Institute of Health Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran ,freshteh_mehri@yahoo.com
2- Hearing Disorders Research Center, Avicenna Institute of Clinical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran & Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Research Center for Health Sciences, Institute of Health Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5- Nutrition Health Research Center, Institute of Health Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract: (18 Views)
Background and Objective: Oxidative stress and antioxidant defense in the pathophysiology of viral infections have received attention in recent years. This study aimed to investigate the levels of oxidative stress in infants with respiratory distress syndrome hospitalized in Fatemeh Hospital compared to a group of healthy infants.
Materials and Methods: This case-control study was conducted on 48 hospitalized infants, including 24 in each group (infants with respiratory distress syndrome compared to healthy infants) in 2024. A total of two milliliters of blood were collected from each infant in heparinized tubes under sterile conditions. Two key biomarkers, total antioxidant capacity (TAC) and malondialdehyde (MDA) were evaluated in the infants' plasma using ELISA. A researcher-made checklist was prepared to collect personal, demographic, and clinical information of the infants.
Results: Our findings show that in infants with respiratory distress syndrome, oxidative stress was higher compared to healthy infants. A significant relationship was found between MDA and TAC levels compared to the control group.
Conclusion: The present study showed that respiratory diseases can increase oxidative stress and reduce antioxidant defense in infants, and consequently increase the risk of diseases.
Materials and Methods: This case-control study was conducted on 48 hospitalized infants, including 24 in each group (infants with respiratory distress syndrome compared to healthy infants) in 2024. A total of two milliliters of blood were collected from each infant in heparinized tubes under sterile conditions. Two key biomarkers, total antioxidant capacity (TAC) and malondialdehyde (MDA) were evaluated in the infants' plasma using ELISA. A researcher-made checklist was prepared to collect personal, demographic, and clinical information of the infants.
Results: Our findings show that in infants with respiratory distress syndrome, oxidative stress was higher compared to healthy infants. A significant relationship was found between MDA and TAC levels compared to the control group.
Conclusion: The present study showed that respiratory diseases can increase oxidative stress and reduce antioxidant defense in infants, and consequently increase the risk of diseases.
Type of Study: Original |
Subject:
Pediatrics (all specialties)
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