Volume 33, Issue 1 (Avicenna Journal of Clinical Medicine-Spring 2026)
Avicenna J Clin Med 2026, 33(1): 21-28 |
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Ahmadi M, Mozaffari Z, Talebi Ghane E. Comparison of the Effect of Dienogest Alone and Dienogest Combined with Zinc on Pain and Quality of Life in Patients with Endometriosis. Avicenna J Clin Med 2026; 33 (1) :21-28
URL: http://sjh.umsha.ac.ir/article-1-3323-en.html
URL: http://sjh.umsha.ac.ir/article-1-3323-en.html
1- Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran & Clinical Research Development Unit of Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran ,zahramozaffari172@yahoo.com
3- Modeling Noncommunicable Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran ,
3- Modeling Noncommunicable Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract: (17 Views)
Background and Objective: Endometriosis is a chronic and inflammatory disease in which an endometrial-like tissue develops outside the uterus. This study was conducted to compare the effects of dienogest alone and dienogest combined with zinc supplementation on pain score and quality of life in patients with endometriosis.
Materials and Methods: This single-blind randomized clinical trial was conducted on 72 patients who were referred to the outpatient clinic of Fatemieh Hospital in Hamadan, Iran, in 2025. Eligible patients were randomly assigned to two groups, A and B. Group A received dienogest (2 mg daily), while Group B received dienogest combined with zinc (50 mg daily) for 4 months. Pain severity was assessed using the Visual Analog Scale (VAS), and quality of life was evaluated using the Endometriosis Health Profile‑30 (EHP-30) questionnaire at baseline and after 4 months. Data were analyzed using SPSS software (version 26).
Results: In the dienogest-alone and dienogest-plus-zinc groups, the mean VAS score before treatment was 6.42 ± 0.50 and 6.53 ± 0.56 (P = 0.304), and after treatment, it was 2.92 ± 0.69 and 2.08 ± 0.65 (P < 0.001), respectively. Improvement in quality of life across all domains of the EHP-30 questionnaire was significantly better in the combination group (P < 0.05). The frequency of side effects was 16.7% and 11.1% in the dienogest-alone and combination therapy groups, respectively (P = 0.496).
Conclusion: It appears that the use of zinc supplementation in combination with dienogest in patients with endometriosis may lead to a reduction in pain and an improvement in endometriosis-related quality of life.
Materials and Methods: This single-blind randomized clinical trial was conducted on 72 patients who were referred to the outpatient clinic of Fatemieh Hospital in Hamadan, Iran, in 2025. Eligible patients were randomly assigned to two groups, A and B. Group A received dienogest (2 mg daily), while Group B received dienogest combined with zinc (50 mg daily) for 4 months. Pain severity was assessed using the Visual Analog Scale (VAS), and quality of life was evaluated using the Endometriosis Health Profile‑30 (EHP-30) questionnaire at baseline and after 4 months. Data were analyzed using SPSS software (version 26).
Results: In the dienogest-alone and dienogest-plus-zinc groups, the mean VAS score before treatment was 6.42 ± 0.50 and 6.53 ± 0.56 (P = 0.304), and after treatment, it was 2.92 ± 0.69 and 2.08 ± 0.65 (P < 0.001), respectively. Improvement in quality of life across all domains of the EHP-30 questionnaire was significantly better in the combination group (P < 0.05). The frequency of side effects was 16.7% and 11.1% in the dienogest-alone and combination therapy groups, respectively (P = 0.496).
Conclusion: It appears that the use of zinc supplementation in combination with dienogest in patients with endometriosis may lead to a reduction in pain and an improvement in endometriosis-related quality of life.
Type of Study: Original |
Subject:
Obstetrics & Gynecology
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