Volume 33, Issue 2 (Avicenna Journal of Clinical Medicine-Summer 2026)
Avicenna J Clin Med 2026, 33(2): 67-73 |
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Farahani F, Hosseini S S, Radnia N, Doosti-Irani A, Gohari N, Emami S F. Studying the Effect of Hormone Replacement Therapy on Tinnitus in Menopausal Women. Avicenna J Clin Med 2026; 33 (2) :67-73
URL: http://sjh.umsha.ac.ir/article-1-3353-en.html
URL: http://sjh.umsha.ac.ir/article-1-3353-en.html
Farhad Farahani1 
, Seyede Shadi Hosseini1 , Nahid Radnia2 , Amin Doosti-Irani3 , Nasrin Gohari4 , Seyede Faranak Emami5
, Seyede Shadi Hosseini1 , Nahid Radnia2 , Amin Doosti-Irani3 , Nasrin Gohari4 , Seyede Faranak Emami5
1- Department of Otorhinolaryngology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Research Center for Health Sciences, Institute of Health Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Audiology, School of Rehabilitation Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Audiology, School of Rehabilitation Sciences, Hamadan University of Medical Sciences, Hamadan, Iran ,faranak_imami@yahoo.com
2- Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Research Center for Health Sciences, Institute of Health Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Audiology, School of Rehabilitation Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Audiology, School of Rehabilitation Sciences, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract: (82 Views)
Background and Objective: Tinnitus in postmenopausal women may worsen due to hormonal changes. This study aimed to determine the effect of hormone replacement therapy (HRT) on tinnitus in postmenopausal women.
Materials and Methods: This study was a triple-blind randomized clinical trial conducted on 35 postmenopausal women with tinnitus. The intervention group consisted of 18 patients who received 0.625 mg of conjugated estrogens and 2.5 mg of medroxyprogesterone daily for three months, and the control group consisted of 17 patients who received placebo. Hearing assessments, Tinnitus Handicap Inventory (THI) questionnaire, Visual Analog Scale (VAS), and Tinnitus Matching Test (TMT) were used. SPSS (version 26) software and Mann-Whitney, Wilcoxon, and Spearman correlation tests were used at a significance level of 0.05.
Results: Before treatment, there was no difference between the two groups. After treatment, tinnitus loudness scores in both groups improved on the THI, TMT, and VAS (P < 0.05). In the intervention group, mean tinnitus loudness scores based on THI (P = 0.02) and TMT (P = 0.00) improved. The difference in mean tinnitus loudness scores before and after treatment, compared to controls, was significant only for THI (P = 0.00). The only significant correlation observed in the intervention group was between tinnitus duration and THI (P = 0.03).
Conclusion: In postmenopausal women, HRT may have potential benefits in reducing tinnitus-related disability. While other measures of tinnitus (visual analog scale, tinnitus matching test) are inconsistent or not significant, we cannot conclude that HRT is an effective intervention for tinnitus.
Materials and Methods: This study was a triple-blind randomized clinical trial conducted on 35 postmenopausal women with tinnitus. The intervention group consisted of 18 patients who received 0.625 mg of conjugated estrogens and 2.5 mg of medroxyprogesterone daily for three months, and the control group consisted of 17 patients who received placebo. Hearing assessments, Tinnitus Handicap Inventory (THI) questionnaire, Visual Analog Scale (VAS), and Tinnitus Matching Test (TMT) were used. SPSS (version 26) software and Mann-Whitney, Wilcoxon, and Spearman correlation tests were used at a significance level of 0.05.
Results: Before treatment, there was no difference between the two groups. After treatment, tinnitus loudness scores in both groups improved on the THI, TMT, and VAS (P < 0.05). In the intervention group, mean tinnitus loudness scores based on THI (P = 0.02) and TMT (P = 0.00) improved. The difference in mean tinnitus loudness scores before and after treatment, compared to controls, was significant only for THI (P = 0.00). The only significant correlation observed in the intervention group was between tinnitus duration and THI (P = 0.03).
Conclusion: In postmenopausal women, HRT may have potential benefits in reducing tinnitus-related disability. While other measures of tinnitus (visual analog scale, tinnitus matching test) are inconsistent or not significant, we cannot conclude that HRT is an effective intervention for tinnitus.
Type of Study: Original |
Subject:
Otorhinolaryngology
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