Introduction: Chronic granulomatous disease (CGD) is an inherited disorder of phagocyte function. The defect of intracellular killing in phagocytes is the cause of recurrent pyogenic infection of patients. Clinical presentations and infections mostly occur during the first 2 years of life and early diagnosis of disease can prevent or decrease the rates of recurrence of infections and mortality.

Case Report: This case report represents a 21 years old man who was admitted and underwent repeated surgery due to pyogenic infections for CGD. The second case was his 20 years old sister who was underwent surgery due to cervical abscess.

Conclusion: This case-report implies that CGD may rarely go undiagnosed until adulthood, so in adults who develop recurrent pyogenic infection, we should be suspicious to CGD, and Nitroblue tetrazolium test is the convenient method for its diagnosis.