Volume 9, Issue 2 (Scientific Journal of Hamadan University of Medical Sciences-Summer 2002)                   Avicenna J Clin Med 2002, 9(2): 0-0 | Back to browse issues page

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Behnam Rasouli M, Nikravesh M R. Study of Maternal Diabetic Effects on Malformation Production in Rat’s Fetus. Avicenna J Clin Med 2002; 9 (2)
URL: http://sjh.umsha.ac.ir/article-1-740-en.html
Abstract:   (4082 Views)

The studies show that there are some embryonic malformation in
   maternal diabetic rats. This malformation may be manifestation in other
   embryonic organs such as skeletal cardiovascular or centeral nervus system. 
   In this study the effects of the maternal hyperglicemia on the processes of
   embryonic evolution,  during rat,s pregnancy were investigated.

          For this aim the beta cells of pancreas  of 7 virgin albino rats were
   chemically destroyed by an injection of 160 mg/Kg alloxan and the same
   manner control group were recived physiological serum. The hyperglicemic
   rats were then mated and at 14th gestational day’s , all of the pregnant 
   rats anesthetized, sacrificed and their  fetuses were collected and fixed in
   10% formalin solution.  After fixation, all of the fetuses  were examined by
   using the stereomicroscope.

          Comparing the experimental with the control group, showed a
   numerical decrease in experimental group.  In addition, the length of 
   Crown-Rump (CR) were decreased significantly in experimental fetuses
   (p<0.001). The rate of the many malformation such as deffect in eyes, ears
   and craniofascial deffect and exencephaly were shown in experimental

          These results suggest that the maternal diabetic may cause some of 
   fetal malformations during pregnancy.

Type of Study: Original | Subject: Other Clinical Specialties

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