Investigation of risk factors leading to cardiac complications in
Kawasaki disease is extremely important because coronary vasculitis may
lead to aneurysmal formation , stenosis and myocardial infarction. Various
laboratory and clinical parameters have been investigated in order to
find the predictive parameters and risk factors for such complications.
In present study we addressed the relationship between intensity of
acute phase response indicators(ESR, CRP, WBC and Platelet counts) and
frequency of cardiovascular complications. 52 admitted children with
Kawasaki disease were included in this retrospective study. Data regarding
the intensity of acute phase reactants were recorded and relationships
between these markers and frequency of cardiovascular problems were
analyzed using statistical methods.
Various cardiovascular abnormalities were demonstrated in 13 cases
(25%) in whom, there were 11 cases with elevated ESR, 6 cases with positive
CRP, 2 cases with leukocytosis and 4 cases with thrombocytosis but in
comparison with non affected group , we didn’t find any significant
correlation between cardiovascular and intensity of acute phase responses.
The intensity of acute phase response indicators such as ESR, CRP, WBC
and Platelet counts can not be regarded as useful predictors for
cardiovascular complications of Kawasaki disease.
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