I report my experience in the treatment of minor recurrent aphthous stomatitis with doses of to 50 to100 mg daily for 3 months a cure was obtained in 21% of cases and marked improvement was evident in the rest.

The follow up period varied from 8 months to 2 years. Four patients experienced Neurophathy and other side effects which disappeared when theme dication was stopped. Thalimide can not be prescribed to women of child bearing potential because of  itsteratogenic potentia.