Volume 26, Issue 2 (Avicenna Journal of Clinical Medicine-Summer 2019)                   Avicenna J Clin Med 2019, 26(2): 110-117 | Back to browse issues page


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Keramat F, Hamzeloui P, Seif Rabiei M A, Saadatmand A. Clinical and Para Clinical Manifestations of HIV-Positive Patients at Different Levels of CD4. Avicenna J Clin Med. 2019; 26 (2) :110-117
URL: http://sjh.umsha.ac.ir/article-1-1919-en.html
1- Professor, Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- General Practitioner, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Associate Professor, Department of Social Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4- MSc in Microbiology, Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran , Ali.s_umsha@yahoo.com
Abstract:   (979 Views)
Background and Objective: Human immunodeficiency virus (HIV)-infected people are at higher risk of opportunistic infections due to immunodeficiency. The current study aimed to evaluate the different levels of CD4 in HIV-infected patients and its relationship with clinical and paraclinical manifestations of the patients.
Materials and Methods: This cross-sectional study was conducted on 94 HIV-infected patients referred to the Counseling Centers for Behavioral Diseases and Sina Hospital in Hamadan, from 2014 to 2015. At the commencement of the study, written consent was obtained from the participants. Thereafter, demographic data, history of underlying diseases, symptoms and clinical syndromes, medical history, and serum CD4 levels were evaluated by flow cytometric recorded in the questionnaire and data were analyzed in SPSS software(version 16).
Results: Out of 66 HIV-positive patients, 70.2% (n=38) were male and the mean age of the patients was 40.06±10. 04 years. In terms of classification of the clinical stage of the disease, the patinets in the first, second, and third stages were reported as 11 (11.7%), 36 (38.3%) and 34 (36.2%), respectively. The mean serum CD4 count of the patients at the beginning of antiretroviral therapy was measured at 284.241±284 and 377.19±271.41 cells /μl, respectively. The difference in the mean of serum CD4 count before and after antiretroviral therapy was revealed to be statistically significant (P=0.001). The most common clinical symptoms observed included cough and sputum (29.9%), oral aphthous ulcer (12.7%), weight loss (11.7%), and fever (7.4%). Based on the results of the study, there was a significant difference between the mean of platelet count, hemoglobin and alkaline phosphatase at different levels of CD4 (P<0.05).
Conclusion: According to the results of the present study, serum CD4 levels rise with the initiation of antiretroviral therapy in HIV infected patients; therefore, early antiretroviral therapy in HIV-infected patients with any serum CD4 level is of paramount importance.
 
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Type of Study: Original | Subject: Infectious Diseases

References
1. Beckwith C, Wing E, Rodriduez B, Lederman M. Human immunodeficiency virus infection and acquired immunodeficiency syndrome. In: Androeli T, Griggs R, Wing E, editors. Andreoli and Carpenter's cecil essentials of medicine e-book: with student consult online access. Philadelphia: Elsevier Health Sciences; 2010. P. 1008-27.
2. Aids and the sustainable development goals. UNAIDS. Available at: URL: http://www.unaids.org/en; 2019.
3. Hygiene health. Ministry of Health and Medical Education. Available at: URL: http://health.behdasht.gov.ir; 2019.
4. Lane HC, Fauci AS. Human immunodeficiency virus disease: AIDS and related disorders. In: Fauci AS, Kasper DL, Longo DL, editor. Harrison’s principle of internal medicine. New York: MacGraw-Hill; 2011. P. 1137-203.
5. Sterling TR, Chaisson RE. General clinical manifestation of HIV infection (including the acute retroviral syndrome and oral, cutaneous, renal, ocular, metabolic and cardiac disease. 7th ed. London: Churchill Livingstone; 2010. P. 1705-25.
6. Cleghorn FR, Reitz MS, Popovic M, Gallo RC. Human immunodeficiency viruses. Bennett's principles and practice of infectious diseases. 6th ed. Philadelphia: Churchill Caurehill Livingston; 2010. P. 1012-4.
7. Mohraz M, Mehrkhani F, Jam S, SeyedAlinaghi S, Sabzvari D, Fattahi F. Seroprevalence of toxoplasmosis in HIV(+)/AIDS patients in Iran. Acta Med Iran. 2011;49(4):213-8. PMID: 21713730
8. Davoodi P, Hamian M, Nourbaksh R, Ahmadi Motamayel F. Oral manifestations related to CD4 lymphocyte count in HIV-positive patients. J Dent Res Dent Clin Dent Prospects. 2010;4(4):115-9. PMID: 23346337 DOI: 10.5681/joddd.2010.029
9. Vinay KV, Sandeep GN, Vishal K, Beena DN. Study of the relationship between CD4 count and clinical features in HIV infected patients in South Indian population. Indian J Fund Appl Life Sci. 2012;2(3):153-61.
10. Jamali E, Vahdat K, Hodavand F. Evaluation of influence of HAART on HIV positive patients in Bushehr hospital. Iran South Med J. 2014;14(3):17-9. [Persian]
11. Agarwal D, Chakravarty J, Sundar S, Gupta V, Bhatia BD. Correlation between clinical features and degree of immunosuppressant in HIV infected children. Indian Pediatr. 2008;45(2):140-3.
12. Crowe SM, Carlin JB, Stewart KI, Lucas CR, Hoy JF. Predictive value of CD4 lymphocyte numbers for the development of opportunistic infections and malignancies in HIV-infected persons. J Acquir Immune Defic Syndr.1991;4(8):770-6. PMID: 1677419
13. Ghate MV, Mehendale SM, Mahajan BA, Yadav R, Brahme RG, Divekar AD, et al. Relationship between clinical conditions and CD4 counts in HIV-infected persons in Pune, Maharashtra, India. Natl Med J India. 2000;13(4):183-7. PMID: 11002684
14. Sharma S, Dhungana GP, Pokhrel BM, Rijal BP. Opportunistic infections in relation to CD4 level among HIV seropositive patients from central Nepal. Nepal Med Coll J. 2010;12(1):1-4. PMID: 20677600
15. Sayad B, Hatami H, Janbakhsh A, Vaziri S, Afsharian M, Rezabeigi M. Survey of clinical syndromes leading to hospitalization in HIV infected patients according to CD4 count in Sina Hospital (Kermanshah). Avicenna J Clin Med. 2006;13(3):51-6. [Persian]

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