Volume 18, Number 1 (Scientific Journal of Hamadan University of Medical Sciences-Spring 2011)                   Sci J Hamadan Univ Med Sci 2011, 18(1): 48-56 | Back to browse issues page


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Vahidinia A A, ShakerHosseini R, Mahjub H. Effect of Antioxidants Supplementation or Restricted Diet on Oxidative Stress in a Rat Model of Diet-Induced Obesity. Sci J Hamadan Univ Med Sci . 2011; 18 (1) :48-56
URL: http://sjh.umsha.ac.ir/article-1-247-en.html

, vahidinia@umsha.ac.ir
Abstract:   (767 Views)

Introduction & Objective: Obesity is independently associated with increased oxidative stress in men and women. Natural antioxidants showed substantial antioxidative and anti-inflammatory activities in vivo. The aim of this study was to examine the preventive effect of antioxidant supplements and/or restricted diet on the stress oxidative index (8-Iso-PGF2α) and total antioxidant capacity (TAC) in obese rats induced by a high-fat (HF) diet.

Material and Methods: In this experimental study forty-eight male Wister rats were randomly assigned to HF purified diet (61% kcal from fat) ad libitum, HF restricted (30%), HF supplemented with astaxanthin, vitamin E and C (HFS), HFS restricted (30%) for 12 weeks. Their daily food intake and weekly body weight gain were measured. Serum 8-Iso-PGF2α and TAC measured by EIA methods.

Results: Energy intake was not significant in HF with HFS (58.8 and 58.6 kcal/rat/d, respectively) and in HF restricted with HFS restricted (41.7 and 41.6 kcal/rat/d, respectively). Serum 8-Iso-PGF2α in HF was 1416.2±443.5 and in HF restricted was 1209.4±424.4pg/ml (p>0.05) and equal for other groups. The lowest TAC was seen in HF and highest was in HFS (0.36±0.43 and 3.0±1.13 mM, respectively) (p<0.001). Conclusions: These results suggest that antioxidant supplements and caloric restriction may improved TAC and partially suppress stress oxidative index in high fat diet induced obese rats.

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Type of Study: Original | Subject: Special

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