Volume 9, Issue 3 (Scientific Journal of Hamadan University of Medical Sciences-Autumn 2002)                   AJCM 2002, 9(3): 0-0 | Back to browse issues page

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Afzali S. The Comparison of Atropine & Atropine + Oxime in Organophosphate Poisoning with Muscarinic Signs . AJCM. 2002; 9 (3)
URL: http://sjh.umsha.ac.ir/article-1-770-en.html
Abstract:   (995 Views)

          Organophosphate insecticides are the choice group  of all  insecticides,
   now, and are the most  common cause of poisoning. Organophosphates
   inhibit acetyl –choline esteras enzyme,specialy in parasympatic synapsies in
   man,and cause muscarinic effects,they also act on somatic nerves and
   autonomic gangelia to present nicotinic effects, and C.N.S manifestation
   may also be demonstrated. Drug treatment in these patients include
   atropine & oximes specially if nicotinic effects are   apparant,oximes will be
   necessary. This investigation compares two different sorts of treatment as
   Atropine & Atropine + Oxime in poisoned patient with organophosphates
   showing muscarinic signs and symptoms.

          This study is an experimental clinical trial and 140 patients being
   poisoned by organophosphates were reffered to special ward of poisoning
   of Sina-Hospital-hamadan, then they were divided into two randomized
   groups and were treated with one of the two kinds of treatment.                                                      

          The results of the treatment using one and two drugs were divided into 3
   categories , i.e. complete recovery , recovery with complication (respiratory
   infection) , and mortality. Complete recovery was 95.5 & 87.9% in cases who
   received one and two drug therapy respectively. Recovery with
   complication was seen in 4.1% and 7.6% of patients using one and two drug
   therapy respectively. Mortality was and 4.5% in cases who received one
   and two drug respectively.

          Statistical calculations and examinations distinguished no expressive
   diversity between these two kinds of treatment.( p- value > 0.05)                                                                                           

Type of Study: Original | Subject: Special

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