Volume 8, Number 1 (Scientific Journal of Hamadan University of Medical Sciences-Spring 2001)                   Sci J Hamadan Univ Med Sci 2001, 8(1): 0-0 | Back to browse issues page


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Ghofrani M, Talebian A, Mostaghimi P. Comparison of Therapeutic Effect of Intravenous Gammaglobuline with Ketogenic Diet in Children with Refractory Epilepsy . Sci J Hamadan Univ Med Sci . 2001; 8 (1)
URL: http://sjh.umsha.ac.ir/article-1-883-en.html

Abstract:   (716 Views)

          Since  of  seizures  in  epileptic  is  in childhood  in  80%  of  cases   and  
   10 to  20% of  these  seizures   are   refractory  to  treatment , this  study  was 
   performed  to  compare  the  efficacy  of  intravenous   gammaglobuline 
   with  ketogenic  diet  in  the  treatment  of  refractory  epilepsy  in  children.

          A  clinical  trial  research  was conducted  on  40 children  with 
   recalcitrant  epilepsy  referred  to  Mophid  Children  Hospital  in  1994. The 
   children  were  devided  to two  "Case" and  "Control" groups  at  random 
   after  partial  matching. Children  in  the  case  group  were  treated  by  IV 
   gammaglobuline  at  a  dose  of 4oo mg/kg/dose   each  three  to  four  
   weeks  for  four  to  six  times  and  those  in  the  control  group  by  mixed 
   Ketogenic  diet. The  frequency  and  duration  of  seizure,
   electroencephalografic  and  behavioral  changes  before  and  after 
   therapy  were  recorded  and  the  result   were  evaluated .

          There  was  a  52%  and  64%  decrease  in  the  average  frequency  of 
   seizures  per  24-hour  in  the  case  and  control  groups,  respectively  . The 
   difference  was  not  statistically  significant. The  duration  of  seizures  was 
   decreased  in  45%  and  60%   of  the  case  and  control  groups 
   respectively.

          Since  there  was  no  significant  difference  in  the  efficacy  of  these 
   two  therapeutic  modalities  and  considering  the  easier  and  the 
   modalities ,  and  considering  the  easier  and  the  more  tolerable  nature 
   of  IV  gammaglobuline, this  method  can  be  used  as  a therapeutic 
   modality  in  recalcitrant  epilepsy.

    

     
Type of Study: Original | Subject: Special

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