Volume 25, Issue 1 (Avicenna Journal of Clinical Medicine - Spring 2018)
Avicenna J Clin Med 2018, 25(1): 5-11 |
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Farshchian M, Sobhan M R, Khanlarzadeh E, Hesari A A. Comparison of the Effects of Salicylic Acid Solution (40%) versus Cryotherapy for the Treatment of Extra-genital Wart . Avicenna J Clin Med 2018; 25 (1) :5-11
URL: http://sjh.umsha.ac.ir/article-1-1692-en.html
URL: http://sjh.umsha.ac.ir/article-1-1692-en.html
1- Professor, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- Assistant Professor, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Assistant Professor, Department of Social Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4- Resident, Department of Dermatology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran ,alihesari39@yahoo.com
2- Assistant Professor, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Assistant Professor, Department of Social Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4- Resident, Department of Dermatology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract: (44003 Views)
Background and Objective: Warts are benign proliferations or mucosal tumors due to infection with various types of human papillomavirus that can affect the skin and mucous membranes. Some warts recover on their own without any effective treatments, but sometimes they need treatment because of pain and other problems, especially beauty issues. We aimed to compare the therapeutic effect of salicylic acid solution (40%) and cryotherapy for the treatment of skin warts.
Materials and Methods: This randomized clinical trial was carried out on patients presenting to clinics and Dermatology Department of Farshchian Hospital in Hamadan, Iran. All the patients were diagnosed with wart. Patients who met the inclusion criteria provided written informed consent. In each patient, one to three warts were randomly treated with cryotherapy and one to three others with salicylic acid solution (40%). After completion of the treatment period, we evaluated improvements and complications in the subjects. Then, the collected data were analyzed using SPSS software.
Results: Overall, we studied 160 warts, which were randomly assigned to cryotherapy and salicylic acid solution (40%) groups (n=80 per group). Regarding the efficacy of treatment, the rates of non-healing, normal skin color, normal lines and both in the cryotherapy group were 6.2%, 27.6%, and 66.2%, respectively, and in the acid salicylic 40% group, these rates were 16.2%, 38.8%, and 42.0%, respectively (P=0.016). The incidence rates of pain, and blistering complications were significantly higher in the cryotherapy group than in the salicylic acid solution (40%) group (P<0.001). There was no significant difference in the effectiveness of treatment with respect to age, gender, and type of wart.
Conclusion: The treatment of extra-genital warts with cryotherapy was more successful than treatment with salicylic acid solution (40%), and there were fewer cases of itching and hyperpigmentation in this group. However, pain and blister complications following cryotherapy were significantly higher than those in the salicylic acid solution (40%) group.
Materials and Methods: This randomized clinical trial was carried out on patients presenting to clinics and Dermatology Department of Farshchian Hospital in Hamadan, Iran. All the patients were diagnosed with wart. Patients who met the inclusion criteria provided written informed consent. In each patient, one to three warts were randomly treated with cryotherapy and one to three others with salicylic acid solution (40%). After completion of the treatment period, we evaluated improvements and complications in the subjects. Then, the collected data were analyzed using SPSS software.
Results: Overall, we studied 160 warts, which were randomly assigned to cryotherapy and salicylic acid solution (40%) groups (n=80 per group). Regarding the efficacy of treatment, the rates of non-healing, normal skin color, normal lines and both in the cryotherapy group were 6.2%, 27.6%, and 66.2%, respectively, and in the acid salicylic 40% group, these rates were 16.2%, 38.8%, and 42.0%, respectively (P=0.016). The incidence rates of pain, and blistering complications were significantly higher in the cryotherapy group than in the salicylic acid solution (40%) group (P<0.001). There was no significant difference in the effectiveness of treatment with respect to age, gender, and type of wart.
Conclusion: The treatment of extra-genital warts with cryotherapy was more successful than treatment with salicylic acid solution (40%), and there were fewer cases of itching and hyperpigmentation in this group. However, pain and blister complications following cryotherapy were significantly higher than those in the salicylic acid solution (40%) group.
Type of Study: Original |
References
1. Bzhalaya D, Eklund C, Dillner J. International standardization and classification of human papillomavirus types. Virology. 2015;476:341-44. [DOI] [PubMed]
2. Kolber MR, Lindblad AJ. HPV vaccine for cancer and wart prevention. Can Fam Physician. 2015;61(1):50. [PubMed]
3. Sterling J. Virus infections. Rook's textbook of dermatology. 7th ed. New Jersey: John Wiley & Sons; 2004. P. 1095-178.
4. Habif TP, Chapman MS, Dinulos JG, Zug KA. Skin disease, diagnosis & treatment. 3rd ed. New York: Elsevier Health Sciences; 2011.
5. Westert GP, Schellevis FG, de Bakker DH, Groenewegen PP, Bensing JM, Van der Zee J. Monitoring health inequalities through general practice: the Second Dutch National Survey of General Practice. Eur J Public Health. 2005;15(1):59-65. [DOI] [PubMed]
6. Lacey CJ, Lowndes CM, Shah KV. Chapter 4 burden and management of non-cancerous HPV-related conditions: HPV-6/11 disease. Vaccine. 2006;24(3):S3/35-41. [DOI] [PubMed]
7. Doorbar J, Quint W, Banks L, Bravo I, Stoler M, Broker T, et al. The biology and life-cycle of human papillomaviruses. Vaccine. 2012;30(5):F55-70. [DOI] [PubMed]
8. Steele K, Irwin WG. Liquid nitrogen and salicylic/lactic acid paint in the treatment of cutaneous warts in general practice. J R Coll Gen Pract. 1988;38(311):256-8. [PubMed]
9. Cockayne S, Curran M, Denby G, Hashmi F, Hewitt C, Hicks K, et al. EVerT: cryotherapy versus salicylic acid for the treatment of verrucae-a randomised controlled trial. Health Technol Assess. 2011;15(32):1-170. [DOI] [PubMed]
10. Stamuli E, Cockayne S, Hewitt C, Hicks K, Jayakody S, Kang'ombe AR, et al. Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial. J Foot Ankle Res. 2012;5(1):4. [DOI] [PubMed]
11. Bruggink SC, Gussekloo J, Egberts PF, Bavinck JNB, de Waal MW, Assendelft WJ, et al. Monochloroacetic acid application is an effective alternative to cryotherapy for common and plantar warts in primary care: a randomized controlled trial. J Invest Dermatol. 2015;135(5):1261-7.
12. Alami Harandi P. Determination the efficacy of cryotherapy in patients referred to the Baqiyatallah Dermatology Clinic for wart from October 1994 until October 1999. Kowsar Med J. 2002;7(2):145-53. [Persian]
13. Alizadegan M, Pashapur F. Determination of cryotherapy efficacy in wart therapy. Urima Med J. 2006;16(4):9-15. [Persian]
14. Shamsi Meymandi S, Mohammad Bagher V, Abroud F. Efficacy of cryotherapy combined with topical cantharidin application versus cryotherapy and placebo in the treatment of verruca vulgaris: a randomized controlled clinical trial. J Dermatol Cosmetic. 2014;5(1):1-8.
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