Introduction & Objective: All cases of gestational trophoblastic tumors are curable if exact diagnosis and early treatment is done. The serum level of βHCG is a sensitive marker of the disease. In this study we intended to compare the "βHCG regression curves" in patients with molar pregnancy and trophoblastic tumor to determine which patients require chemotherapy and should start early treatment.

Materials & Methods: Recorded data of 80 patients, consisting of 40 uneventful hydatiform mole cases and 40 trophoblastic tumor patients referred to Meshed Ghaem gynecology clinic were gathered and studied.

Results: Mean age was 26.7 years in the molar group and 27 in the gestational trophoblastic tumor group. There was a history of abortion in the past in 25% of the patients of both groups. 67.5% of patients were in the stage 1 and thus were 100% curable. The βHCG regression curve exceeded the normal range in the gestational trophoblastic tumors groups (P= 0.001).

Conclusion: This study showed that βHCG regression curve can be used to diagnose these tumors much earlier (a few weeks after evacuation) and thus start treatment sooner.