Volume 32, Issue 3 (Avicenna Journal of Clinical Medicine-Autumn 2025)
Avicenna J Clin Med 2025, 32(3): 133-139 |
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Pazoki Anzehaei M, Joghataei P, Pourahmadi S. Cardiac Function with Emphasis on the GLS Index in Parkinson’s Disease Patients Undergoing Deep Brain Stimulation: A Comparative Study between DBS Candidates and Recipients. Avicenna J Clin Med 2025; 32 (3) :133-139
URL: http://sjh.umsha.ac.ir/article-1-3250-en.html
URL: http://sjh.umsha.ac.ir/article-1-3250-en.html
1- Department of Cardiology, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran
2- Department of Cardiology, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran ,saharpourahamadi@gmail.com
2- Department of Cardiology, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran ,
Abstract: (1 Views)
Background and Objective: Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease. Deep brain stimulation (DBS) in these patients may affect cardiovascular system function. This study aimed to compare cardiac function indices, including Global Longitudinal Strain (GLS), between Parkinson’s disease patients who are candidates for DBS and those who are receiving DBS.
Materials and Methods: This prospective observational cohort study involved 37 Parkinson’s patients aged 18 years or older who were candidates for DBS surgery. Patients who had received DBS were compared with those who had not yet undergone the procedure. Cardiac indices, such as GLS, LVEDV, LVEF, and other echocardiographic parameters, were assessed. Data were analyzed using Student's t-test, chi-square, and Fisher's exact tests.
Results: The mean age of participants (n=37) was 57.7 ± 16.9 years (age range: 29 to 89), and the majority of the patients (n=23, 62.2%) were male. No significant differences were found between the two groups in terms of mean GLS, LVEDV, LVESV, LVEF, SPAP, E/e', E, and A (P > 0.05). However, the mean e' was significantly higher in the DBS group (9.62 ± 0.66 vs. 9.08 ± 0.8, P = 0.046).
Conclusion: The leading cardiac function indices, including GLS, did not differ significantly between patients with and without DBS. Nevertheless, the significant increase in e' in the DBS group indicates an improvement in diastolic cardiac function in these patients.
Materials and Methods: This prospective observational cohort study involved 37 Parkinson’s patients aged 18 years or older who were candidates for DBS surgery. Patients who had received DBS were compared with those who had not yet undergone the procedure. Cardiac indices, such as GLS, LVEDV, LVEF, and other echocardiographic parameters, were assessed. Data were analyzed using Student's t-test, chi-square, and Fisher's exact tests.
Results: The mean age of participants (n=37) was 57.7 ± 16.9 years (age range: 29 to 89), and the majority of the patients (n=23, 62.2%) were male. No significant differences were found between the two groups in terms of mean GLS, LVEDV, LVESV, LVEF, SPAP, E/e', E, and A (P > 0.05). However, the mean e' was significantly higher in the DBS group (9.62 ± 0.66 vs. 9.08 ± 0.8, P = 0.046).
Conclusion: The leading cardiac function indices, including GLS, did not differ significantly between patients with and without DBS. Nevertheless, the significant increase in e' in the DBS group indicates an improvement in diastolic cardiac function in these patients.
Type of Study: Original |
Subject:
Cardiovascular Diseases
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