Volume 7, Number 1 (Scientific Journal of Hamadan University of Medical Sciences-Spring 2000)                   Sci J Hamadan Univ Med Sci 2000, 7(1): 0-0 | Back to browse issues page


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Jalali M, Parivar K, Nikravesh M, Hossieni-Ravesh M. The Teratogenic Effects of Acetaminophen on the Mice Embryo. Sci J Hamadan Univ Med Sci . 2000; 7 (1)
URL: http://sjh.umsha.ac.ir/article-1-952-en.html

Abstract:   (717 Views)

         Acetaminophen is a  widely used  analegesis and antipyretic which is

   considered  safe  at  therapeutic  levels . This  medicine is  also  a  kind  of

   influensive substiution via the gut, it is metabolized in liver and  converted

   to consistant  and  potential  toxic  metabolits . Acetaminophen  and  it’s

   metabolits  undifficulty passes from decidua and achieves  emberyo and

   is the cause of malformations in emberyo.

         In this investigation   we   basically   found   that   the  consumption  of

   therapeutic   does  of  acetaminophen  ( 48.5  mg/kg )  in   mice ,  during

   sensitive  organogenesis  days   ( 7,8,9  and  9,10,11  pregnancy )  caused

   abnormalities  that  the  most  important  of  them  included :decrease of

   weight   of  emberyo’s   body  in  comparison  with control group(P<0.05).

   Another   abnormalities   observed    in    this    study  :  decrease  of    CR ,

   exencephally ,   absorption   of  embryo  and  skeletal  system  defect.  In

   resumption of  research, we also treared  the double  of  the  therapeutic

   dose (97  mg/kg)  in  sensitive  organogenesis period  to  pregnant mouse

   via the animal feeding , it caused  increasing  of the  abnormalities .  As it

   shows  that  there  is  significant decrease in weight and CR in comparison

   with control group.

     
Type of Study: Original | Subject: Special

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